Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)
1_MATAP 6_ SYPAG 11_ LPGSP 16_ GPGSP 21_ PPPGG 26_ LELQS 31_ PPPLL 36_ PQIPA 41_ PGSGV 46_ SFHIQ 51_ IGLTR 56_ EFVLL 61_ PAASE 66_ LAHVK 71_ QLACS 76_ IVDQK 81_ FPECG 86_ FYGLY 91_ DKILL 96_ FKHDP 101_ TSANL 106_ LQLVR 111_ SSGDI 116_ QEGDL 121_ VEVVL 126_ SASAT 131_ FEDFQ 136_ IRPHA 141_ LTVHS 146_ YRAPA 151_ FCDHC 156_ GEMLF 161_ GLVRQ 166_ GLKCD 171_ GCGLN 176_ YHKRC 181_ AFSIP 186_ NNCSG 191_ ARKRR 196_ LSSTS 201_ LASGH 206_ SVRLG 211_ TSESL 216_ PCTAE 221_ ELSRS 226_ TTELL 231_ PRRPP 236_ SSSSS 241_ SSASS 246_ YTGRP 251_ IELDK 256_ MLLSK 261_ VKVPH 266_ TFLIH 271_ SYTRP 276_ TVCQA 281_ CKKLL 286_ KGLFR 291_ QGLQC 296_ KDCKF 301_ NCHKR 306_ CATRV 311_ PNDCL 316_ GEALI 321_ NGDVP 326_ MEEAT 331_ DFSEA 336_ DKSAL 341_ MDESE 346_ DSGVI 351_ PGSHS 356_ ENALH 361_ ASEEE 366_ EGEGG 371_ KAQSS 376_ LGYIP 381_ LMRVV 386_ QSVRH 391_ TTRKS 396_ STTLR 401_ EGWVV 406_ HYSNK 411_ DTLRK 416_ RHYWR 421_ LDCKC 426_ ITLFQ 431_ NNTTN 436_ RYYKE 441_ IPLSE 446_ ILTVE 451_ SAQNF 456_ SLVPP 461_ GTNPH 466_ CFEIV 471_ TANAT 476_ YFVGE 481_ MPGGT 486_ PGGPS 491_ GQGAE 496_ AARGW 501_ ETAIR 506_ QALMP 511_ VILQD 516_ APSAP 521_ GHAPH 526_ RQASL 531_ SISVS 536_ NSQIQ 541_ ENVDI 546_ ATVYQ 551_ IFPDE 556_ VLGSG 561_ QFGVV 566_ YGGKH 571_ RKTGR 576_ DVAVK 581_ VIDKL 586_ RFPTK 591_ QESQL 596_ RNEVA 601_ ILQSL 606_ RHPGI 611_ VNLEC 616_ MFETP 621_ EKVFV 626_ VMEKL 631_ HGDML 636_ EMILS 641_ SEKGR 646_ LPERL 651_ TKFLI 656_ TQILV 661_ ALRHL 666_ HFKNI 671_ VHCDL 676_ KPENV 681_ LLASA 686_ DPFPQ 691_ VKLCD 696_ FGFAR 701_ IIGEK 706_ SFRRS 711_ VVGTP 716_ AYLAP 721_ EVLLN 726_ QGYNR 731_ SLDMW 736_ SVGVI 741_ MYVSL 746_ SGTFP 751_ FNEDE 756_ DINDQ 761_ IQNAA 766_ FMYPA 771_ SPWSH 776_ ISAGA 781_ IDLIN 786_ NLLQV 791_ KMRKR 796_ YSVDK 801_ SLSHP 806_ WLQEY 811_ QTWLD 816_ LRELE 821_ GKMGE 826_ RYITH 831_ ESDDA 836_ RWEQF 841_ AAEHP 846_ LPGSG 851_ LPTDR 856_ DLGGA 861_ CPPQD 866_ HDMQG 871_LAERI
1: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467)