Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)
1_MALLS 6_ RPALT 11_ LLLLL 16_ MAAVV 21_ RCQEQ 26_ AQTTD 31_ WRATL 36_ KTIRN 41_ GVHKI 46_ DTYLN 51_ AALDL 56_ LGGED 61_ GLCQY 66_ KCSDG 71_ SKPFP 76_ RYGYK 81_ PSPPN 86_ GCGSP 91_ LFGVH 96_ LNIGI 101_ PSLTK 106_ CCNQH 111_ DRCYE 116_ TCGKS 121_ KNDCD 126_ EEFQY 131_ CLSKI 136_ CRDVQ 141_ KTLGL 146_ TQHVQ 151_ ACETT 156_ VELLF 161_ DSVIH 166_ LGCKP 171_ YLDSQ 176_ RAACR 181_CHYEE
1: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine