Group IIF secretory phospholipase A2 (GIIF sPLA2) (sPLA2-IIF) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2F)
1_MKKFF 6_ TVAIL 11_ AGSVL 16_ STAHG 21_ SLLNL 26_ KAMVE 31_ AVTGR 36_ SAILS 41_ FVGYG 46_ CYCGL 51_ GGRGQ 56_ PKDEV 61_ DWCCH 66_ AHDCC 71_ YQELF 76_ DQGCH 81_ PYVDH 86_ YDHTI 91_ ENNTE 96_ IVCSD 101_ LNKTE 106_ CDKQT 111_ CMCDK 116_ NMVLC 121_ LMNQT 126_ YREEY 131_ RGFLN 136_ VYCQG 141_ PTPNC 146_ SIYEP 151_ PPEEV 156_ TCSHQ 161_SPAPP
1: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11112443). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity)