GS homeobox 2 (Genetic-screened homeobox 2) (Homeobox protein GSH-2)
1_MSRSF 6_ YVDSL 11_ IIKDT 16_ SRPAP 21_ SLPEP 26_ HPGPD 31_ FFIPL 36_ GMPPP 41_ LVMSV 46_ SGPGC 51_ PSRKS 56_ GAFCV 61_ CPLCV 66_ TSHLH 71_ SSRGS 76_ VGAGS 81_ GGAGA 86_ GVTGA 91_ GGSGV 96_ AGAAG 101_ ALPLL 106_ KGQFS 111_ SAPGD 116_ AQFCP 121_ RVNHA 126_ HHHHH 131_ PPQHH 136_ HHHHQ 141_ PQQPG 146_ SAAAA 151_ AAAAA 156_ AAAAA 161_ AALGH 166_ PQHHA 171_ PVCTA 176_ TTYNV 181_ ADPRR 186_ FHCLT 191_ MGGSD 196_ ASQVP 201_ NGKRM 206_ RTAFT 211_ STQLL 216_ ELERE 221_ FSSNM 226_ YLSRL 231_ RRIEI 236_ ATYLN 241_ LSEKQ 246_ VKIWF 251_ QNRRV 256_ KHKKE 261_ GKGTQ 266_ RNSHA 271_ GCKCV 276_ GSQVH 281_ YARSE 286_ DEDSL 291_ SPASA 296_NDDKE
1: Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed:31412107). During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity)