Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902)
1_MTKLI 6_ LLTGL 11_ VLILN 16_ LQLGS 21_ AYQLT 26_ CYFTN 31_ WAQYR 36_ PGLGR 41_ FMPDN 46_ IDPCL 51_ CTHLI 56_ YAFAG 61_ RQNNE 66_ ITTIE 71_ WNDVT 76_ LYQAF 81_ NGLKN 86_ KNSQL 91_ KTLLA 96_ IGGWN 101_ FGTAP 106_ FTAMV 111_ STPEN 116_ RQTFI 121_ TSVIK 126_ FLRQY 131_ EFDGL 136_ DFDWE 141_ YPGSR 146_ GSPPQ 151_ DKHLF 156_ TVLVQ 161_ EMREA 166_ FEQEA 171_ KQINK 176_ PRLMV 181_ TAAVA 186_ AGISN 191_ IQSGY 196_ EIPQL 201_ SQYLD 206_ YIHVM 211_ TYDLH 216_ GSWEG 221_ YTGEN 226_ SPLYK 231_ YPTDT 236_ GSNAY 241_ LNVDY 246_ VMNYW 251_ KDNGA 256_ PAEKL 261_ IVGFP 266_ TYGHN 271_ FILSN 276_ PSNTG 281_ IGAPT 286_ SGAGP 291_ AGPYA 296_ KESGI 301_ WAYYE 306_ ICTFL 311_ KNGAT 316_ QGWDA 321_ PQEVP 326_ YAYQG 331_ NVWVG 336_ YDNIK 341_ SFDIK 346_ AQWLK 351_ HNKFG 356_ GAMVW 361_ AIDLD 366_ DFTGT 371_ FCNQG 376_ KFPLI 381_ STLKK 386_ ALGLQ 391_ SASCT 396_ APAQP 401_ IEPIT 406_ AAPSG 411_ SGNGS 416_ GSSSS 421_ GGSSG 426_ GSGFC 431_ AVRAN 436_ GLYPV 441_ ANNRN 446_ AFWHC 451_ VNGVT 456_ YQQNC 461_ QAGLV 466_ FDTSC 471_DCCNW
1: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding