Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMN/NaMN adenylyltransferase 2) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 2) (NMN adenylyltransferase 2) (Nicotinate-nucleotide adenylyltransferase 2) (NaMN adenylyltransferase 2)
1_MTETT 6_ KTHVI 11_ LLACG 16_ SFNPI 21_ TKGHI 26_ QMFER 31_ ARDYL 36_ HKTGR 41_ FIVIG 46_ GIVSP 51_ VHDSY 56_ GKQGL 61_ VSSRH 66_ RLIMC 71_ QLAVQ 76_ NSDWI 81_ RVDPW 86_ ECYQD 91_ TWQTT 96_ CSVLE 101_ HHRDL 106_ MKRVT 111_ GCILS 116_ NVNTP 121_ SMTPV 126_ IGQPQ 131_ NETPQ 136_ PIYQN 141_ SNVAT 146_ KPTAA 151_ KILGK 156_ VGESL 161_ SRICC 166_ VRPPV 171_ ERFTF 176_ VDENA 181_ NLGTV 186_ MRYEE 191_ IELRI 196_ LLLCG 201_ SDLLE 206_ SFCIP 211_ GLWNE 216_ ADMEV 221_ IVGDF 226_ GIVVV 231_ PRDAA 236_ DTDRI 241_ MNHSS 246_ ILRKY 251_ KNNIM 256_ VVKDD 261_ INHPM 266_ SVVSS 271_ TKSRL 276_ ALQHG 281_ DGHVV 286_ DYLSQ 291_ PVIDY 296_ ILKSQ 301_LYINA
1: Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (PubMed:34314702). May be involved in the maintenance of axonal integrity (By similarity)