ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)
1_MSEAG 6_ GRGCG 11_ SPVPQ 16_ RARWR 21_ LVAAT 26_ AAFCL 31_ VSATS 36_ VWTAG 41_ AEPMS 46_ REEKQ 51_ KLGNQ 56_ VLEMF 61_ DHAYG 66_ NYMEH 71_ AYPAD 76_ ELMPL 81_ TCRGR 86_ VRGQE 91_ PSRGD 96_ VDDAL 101_ GKFSL 106_ TLIDS 111_ LDTLV 116_ VLNKT 121_ KEFED 126_ AVRKV 131_ LRDVN 136_ LDNDV 141_ VVSVF 146_ ETNIR 151_ VLGGL 156_ LGGHS 161_ LAIML 166_ KEKGE 171_ YMQWY 176_ NDELL 181_ QMAKQ 186_ LGYKL 191_ LPAFN 196_ TTSGL 201_ PYPRI 206_ NLKFG 211_ IRKPE 216_ ARTGT 221_ ETDTC 226_ TACAG 231_ TLILE 236_ FAALS 241_ RFTGA 246_ TIFEE 251_ YARKA 256_ LDFLW 261_ EKRQR 266_ SSNLV 271_ GVTIN 276_ IHTGD 281_ WVRKD 286_ SGVGA 291_ GIDSY 296_ YEYLL 301_ KAYVL 306_ LGDDS 311_ FLERF 316_ NTHYD 321_ AIMRY 326_ ISQPP 331_ LLLDV 336_ HIHKP 341_ MLNAR 346_ TWMDA 351_ LLAFF 356_ PGLQV 361_ LKGDI 366_ RPAIE 371_ THEML 376_ YQVIK 381_ KHNFL 386_ PEAFT 391_ TDFRV 396_ HWAQH 401_ PLRPE 406_ FAEST 411_ YFLYK 416_ ATGDP 421_ YYLEV 426_ GKTLI 431_ ENLNK 436_ YARVP 441_ CGFAA 446_ MKDVR 451_ TGSHE 456_ DRMDS 461_ FFLAE 466_ MFKYL 471_ YLLFA 476_ DKEDI 481_ IFDIE 486_ DYIFT 491_ TEAHL 496_ LPLWL 501_ STTNQ 506_ SISKK 511_ NTTSE 516_ YTELD 521_ DSNFD 526_ WTCPN 531_ TQILF 536_ PNDPL 541_ YAQSI 546_ REPLK 551_ NVVDK 556_ SCPRG 561_ IIRVE 566_ ESFRS 571_ GAKPP 576_ LRARD 581_ FMATN 586_ PEHLE 591_ ILKKM 596_ GVSLI 601_ HLKDG 606_ RVQLV 611_ QHAIQ 616_ AASSI 621_ DAEDG 626_ LRFMQ 631_ EMIEL 636_ SSQQQ 641_ KEQQL 646_ PPRAV 651_ QIVSH 656_ PFFGR 661_ VVLTA 666_ GPAQF 671_ GLDLS 676_ KHKET 681_ RGFVA 686_ SSKPS 691_ NGCSE 696_ LTNPE 701_ AVMGK 706_ IALIQ 711_ RGQCM 716_ FAEKA 721_ RNIQN 726_ AGAIG 731_ GIVID 736_ DNEGS 741_ SSDTA 746_ PLFQM 751_ AGDGK 756_ DTDDI 761_ KIPML 766_ FLFSK 771_ EGSII 776_ LDAIR 781_ EYEEV 786_ EVLLS 791_ DKAKD 796_ RDPEM 801_ ENEEQ 806_ PSSEN 811_ DSQNQ 816_ SGEQI 821_ SSSSQ 826_ EVDLV 831_ DQESS 836_ EENSL 841_ NSHPE 846_ SLSLA 851_ DMDNA 856_ ASISP 861_ SEQTS 866_ NPTEN 871_ HETTN 876_ LNGEC 881_ TDLDN 886_ QLQEQ 891_ SETEE 896_ DSNPN 901_ VSWGK 906_ KVQPI 911_ DSILA 916_ DWNED 921_ IEAFE 926_MMEKD
1: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans (PubMed:25092655). May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952). May have alpha 1,2-mannosidase activity (By similarity)