Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor)
1_MKRAS 6_ AGGSR 11_ LLAWV 16_ LWLQA 21_ WQVAA 26_ PCPGA 31_ CVCYN 36_ EPKVT 41_ TSCPQ 46_ QGLQA 51_ VPVGI 56_ PAASQ 61_ RIFLH 66_ GNRIS 71_ HVPAA 76_ SFRAC 81_ RNLTI 86_ LWLHS 91_ NVLAR 96_ IDAAA 101_ FTGLA 106_ LLEQL 111_ DLSDN 116_ AQLRS 121_ VDPAT 126_ FHGLG 131_ RLHTL 136_ HLDRC 141_ GLQEL 146_ GPGLF 151_ RGLAA 156_ LQYLY 161_ LQDNA 166_ LQALP 171_ DDTFR 176_ DLGNL 181_ THLFL 186_ HGNRI 191_ SSVPE 196_ RAFRG 201_ LHSLD 206_ RLLLH 211_ QNRVA 216_ HVHPH 221_ AFRDL 226_ GRLMT 231_ LYLFA 236_ NNLSA 241_ LPTEA 246_ LAPLR 251_ ALQYL 256_ RLNDN 261_ PWVCD 266_ CRARP 271_ LWAWL 276_ QKFRG 281_ SSSEV 286_ PCSLP 291_ QRLAG 296_ RDLKR 301_ LAAND 306_ LQGCA 311_ VATGP 316_ YHPIW 321_ TGRAT 326_ DEEPL 331_ GLPKC 336_ CQPDA 341_ ADKAS 346_ VLEPG 351_ RPASA 356_ GNALK 361_ GRVPP 366_ GDSPP 371_ GNGSG 376_ PRHIN 381_ DSPFG 386_ TLPGS 391_ AEPPL 396_ TAVRP 401_ EGSEP 406_ PGFPT 411_ SGPRR 416_ RPGCS 421_ RKNRT 426_ RSHCR 431_ LGQAG 436_ SGGGG 441_ TGDSE 446_ GSGAL 451_ PSLTC 456_ SLTPL 461_ GLALV 466_LWTVL
1: Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12089450, PubMed:12426574, PubMed:12839991, PubMed:16712417, PubMed:18411262, PubMed:19052207). Functions as a receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as a receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200)