E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
1_MAENW 6_ KNCFE 11_ EELIC 16_ PICLH 21_ VFVEP 26_ VQLPC 31_ KHNFC 36_ RGCIG 41_ EAWAK 46_ DSGLV 51_ RCPEC 56_ NQAYN 61_ QKPGL 66_ EKNLK 71_ LTNIV 76_ EKFNA 81_ LHVEK 86_ PPAAL 91_ HCVFC 96_ RRGPP 101_ LPAQK 106_ VCLRC 111_ EAPCC 116_ QSHVQ 121_ THLQQ 126_ PSTAR 131_ GHLLV 136_ EADDV 141_ RAWSC 146_ PQHNA 151_ YRLYH 156_ CEAEQ 161_ VAVCQ 166_ YCCYY 171_ SGAHQ 176_ GHSVC 181_ DVEIR 186_ RNEIR 191_ KMLMK 196_ QQDRL 201_ EEREQ 206_ DIEDQ 211_ LYKLE 216_ SDKRL 221_ VEEKV 226_ NQLKE 231_ EVRLQ 236_ YEKLH 241_ QLLDE 246_ DLRQT 251_ VEVLD 256_ KAQAK 261_ FCSEN 266_ AAQAL 271_ HLGER 276_ MQEAK 281_ KLLGS 286_ LQLLF 291_ DKTED 296_ VSFMK 301_ NTKSV 306_ KILMD 311_ RTQTC 316_ TSSSL 321_ SPTKI 326_ GHLNS 331_ KLFLN 336_ EVAKK 341_ EKQLR 346_ KMLEG 351_ PFSTP 356_ VPFLQ 361_ SVPLY 366_ PCGVS 371_ SSGAE 376_ KRKHS 381_ TAFPE 386_ ASFLE 391_ TSSGP 396_ VGGQY 401_ GAAGT 406_ ASGEG 411_ QSGQP 416_ LGPCS 421_ STQHL 426_ VALPG 431_ GAQPV 436_ HSSPV 441_ FPPSQ 446_ YPNGS 451_ AAQQP 456_ MLPQY 461_ GGRKI 466_ LVCSV 471_ DNCYC 476_ SSVAN 481_ HGGHQ 486_ PYPRS 491_ GHFPW 496_ TVPSQ 501_ EYSHP 506_ LPPTP 511_ SVPQS 516_ LPSLA 521_ VRDWL 526_ DASQQ 531_ PGHQD 536_ FYRVY 541_ GQPST 546_KHYVT
1: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:27981609, PubMed:28747347). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791, PubMed:27981609, PubMed:34871740). Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347)