Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form]
1_MPNPR 6_ PGKPS 11_ APSLA 16_ LGPSP 21_ GASPS 26_ WRAAP 31_ KASDL 36_ LGARG 41_ PGGTF 46_ QGRDL 51_ RGGAH 56_ ASSSS 61_ LNPMP 66_ PSQLQ 71_ LPTLP 76_ LVMVA 81_ PSGAR 86_ LGPLP 91_ HLQAL 96_ LQDRP 101_ HFMHQ 106_ LSTVD 111_ AHART 116_ PVLQV 121_ HPLES 126_ PAMIS 131_ LTPPT 136_ TATGV 141_ FSLKA 146_ RPGLP 151_ PGINV 156_ ASLEW 161_ VSREP 166_ ALLCT 171_ FPNPS 176_ APRKD 181_ STLSA 186_ VPQSS 191_ YPLLA 196_ NGVCK 201_ WPGCE 206_ KVFEE 211_ PEDFL 216_ KHCQA 221_ DHLLD 226_ EKGRA 231_ QCLLQ 236_ REMVQ 241_ SLEQQ 246_ LVLEK 251_ EKLSA 256_ MQAHL 261_ AGKMA 266_ LTKAS 271_ SVASS 276_ DKGSC 281_ CIVAA 286_ GSQGP 291_ VVPAW 296_ SGPRE 301_ APDSL 306_ FAVRR 311_ HLWGS 316_ HGNST 321_ FPEFL 326_ HNMDY 331_ FKFHN 336_ MRPPF 341_ TYATL 346_ IRWAI 351_ LEAPE 356_ KQRTL 361_ NEIYH 366_ WFTRM 371_ FAFFR 376_ NHPAT 381_ WKNAI 386_ RHNLS 391_ LHKCF 396_ VRVES 401_ EKGAV 406_ WTVDE 411_ LEFRK 416_ KRSQR 421_ PSRCS 426_NPTPG
1: Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity)