UBX domain-containing protein 6 (UBX domain-containing protein 1)
1_MKKFF 6_ QEFKA 11_ DIKFK 16_ SAGPG 21_ QKLKE 26_ SVGEK 31_ AHKEK 36_ PNQPA 41_ PRPPR 46_ QGPTN 51_ EAQMA 56_ AAAAL 61_ ARLEQ 66_ KQSRA 71_ WGPTS 76_ QDTIR 81_ NQVRK 86_ ELQAE 91_ ATVSG 96_ SPEAP 101_ GTNVV 106_ SEPRE 111_ EGSAH 116_ LAVPG 121_ VYFTC 126_ PLTGA 131_ TLRKD 136_ QRDAC 141_ IKEAI 146_ LLHFS 151_ TDPVA 156_ ASIMK 161_ IYTFN 166_ KDQDR 171_ VKLGV 176_ DTIAK 181_ YLDNI 186_ HLHPE 191_ EEKYR 196_ KIKLQ 201_ NKVFQ 206_ ERINC 211_ LEGTH 216_ EFFEA 221_ IGFQK 226_ VLLPA 231_ QDQED 236_ PEEFY 241_ VLSET 246_ TLAQP 251_ QSLER 256_ HKEQL 261_ LAAEP 266_ VRAKL 271_ DRQRR 276_ VFQPS 281_ PLASQ 286_ FELPG 291_ DFFNL 296_ TAEEI 301_ KREQR 306_ LRSEA 311_ VERLS 316_ VLRTK 321_ AMREK 326_ EEQRG 331_ LRKYN 336_ YTLLR 341_ VRLPD 346_ GCLLQ 351_ GTFYA 356_ RERLG 361_ AVYGF 366_ VREAL 371_ QSDWL 376_ PFELL 381_ ASGGQ 386_ KLSED 391_ ENLAL 396_ NECGL 401_ VPSAL 406_ LTFSW 411_ DMAVL 416_ EDIKA 421_ AGAEP 426_ DSILK 431_ PELLS 436_AIEKL
1: May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622)