Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
1_MLGQV 6_ VTLIL 11_ LLLLK 16_ VYQGK 21_ GCQGS 26_ ADHVV 31_ SISGV 36_ PLQLQ 41_ PNSIQ 46_ TKVDS 51_ IAWKK 56_ LLPSQ 61_ NGFHH 66_ ILKWE 71_ NGSLP 76_ SNTSN 81_ DRFSF 86_ IVKNL 91_ SLLIK 96_ AAQQQ 101_ DSGLY 106_ CLEVT 111_ SISGK 116_ VQTAT 121_ FQVFV 126_ FESLL 131_ PDKVE 136_ KPRLQ 141_ GQGKI 146_ LDRGR 151_ CQVAL 156_ SCLVS 161_ RDGNV 166_ SYAWY 171_ RGSKL 176_ IQTAG 181_ NLTYL 186_ DEEVD 191_ INGTH 196_ TYTCN 201_ VSNPV 206_ SWESH 211_ TLNLT 216_ QDCQN 221_ AHQEF 226_ RFWPF 231_ LVIIV 236_ ILSAL 241_ FLGTL 246_ ACFCV 251_ WRRKR 256_ KEKQS 261_ ETSPK 266_ EFLTI 271_ YEDVK 276_ DLKTR 281_ RNHEQ 286_ EQTFP 291_ GGGST 296_ IYSMI 301_ QSQSS 306_ APTSQ 311_ EPAYT 316_ LYSLI 321_ QPSRK 326_ SGSRK 331_ RNHSP 336_ SFNST 341_ IYEVI 346_ GKSQP 351_ KAQNP 356_ ARLSR 361_KELEN
1: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:11714776, PubMed:8376943). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:11714776, PubMed:8376943). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity)