Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2)
1_MAGDS 6_ EQTLQ 11_ NHQQP 16_ NGGEP 21_ FLIGV 26_ SGGTA 31_ SGKSS 36_ VCAKI 41_ VQLLG 46_ QNEVD 51_ YRQKQ 56_ VVILS 61_ QDSFY 66_ RVLTS 71_ EQKAK 76_ ALKGQ 81_ FNFDH 86_ PDAFD 91_ NELIL 96_ KTLKE 101_ ITEGK 106_ TVQIP 111_ VYDFV 116_ SHSRK 121_ EETVT 126_ VYPAD 131_ VVLFE 136_ GILAF 141_ YSQEV 146_ RDLFQ 151_ MKLFV 156_ DTDAD 161_ TRLSR 166_ RVLRD 171_ ISERG 176_ RDLEQ 181_ ILSQY 186_ ITFVK 191_ PAFEE 196_ FCLPT 201_ KKYAD 206_ VIIPR 211_ GADNL 216_ VAINL 221_ IVQHI 226_ QDILN 231_ GGPSK 236_ RQTNG 241_ CLNGY 246_ TPSRK 251_ RQASE 256_SSSRP
1: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702, PubMed:11494055). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702)