E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM31) (Tripartite motif-containing protein 31)
1_MASGQ 6_ FVNKL 11_ QEEVI 16_ CPICL 21_ DILQK 26_ PVTID 31_ CGHNF 36_ CLKCI 41_ TQIGE 46_ TSCGF 51_ FKCPL 56_ CKTSV 61_ RKNAI 66_ RFNSL 71_ LRNLV 76_ EKIQA 81_ LQASE 86_ VQSKR 91_ KEATC 96_ PRHQE 101_ MFHYF 106_ CEDDG 111_ KFLCF 116_ VCRES 121_ KDHKS 126_ HNVSL 131_ IEEAA 136_ QNYQG 141_ QIQEQ 146_ IQVLQ 151_ QKEKE 156_ TVQVK 161_ AQGVH 166_ RVDVF 171_ TDQVE 176_ HEKQR 181_ ILTEF 186_ ELLHQ 191_ VLEEE 196_ KNFLL 201_ SRIYW 206_ LGHEG 211_ TEAGK 216_ HYVAS 221_ TEPQL 226_ NDLKK 231_ LVDSL 236_ KTKQN 241_ MPPRQ 246_ LLEDI 251_ KVVLC 256_ RSEEF 261_ QFLNP 266_ TPVPL 271_ ELEKK 276_ LSEAK 281_ SRHDS 286_ ITGSL 291_ KKFKD 296_ QLQAD 301_ RKKDE 306_ NRFFK 311_ SMNKN 316_ DMKSW 321_ GLLQK 326_ NNHKM 331_ NKTSE 336_ PGSSS 341_ AGGRT 346_ TSGPP 351_ NHHSS 356_ APSHS 361_ LFRAS 366_ SAGKV 371_ TFPVC 376_ LLASY 381_ DEISG 386_ QGASS 391_ QDTKT 396_ FDVAL 401_ SEELH 406_ AALSE 411_ WLTAI 416_RAWFC
1: E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:18773414, PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (By similarity)