Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169)
1_MGFLP 6_ KLLLL 11_ ASFFP 16_ AGQAS 21_ WGVSS 26_ PQDVQ 31_ GVKGS 36_ CLLIP 41_ CIFSF 46_ PADVE 51_ VPDGI 56_ TAIWY 61_ YDYSG 66_ QRQVV 71_ SHSAD 76_ PKLVE 81_ ARFRG 86_ RTEFM 91_ GNPEH 96_ RVCNL 101_ LLKDL 106_ QPEDS 111_ GSYNF 116_ RFEIS 121_ EVNRW 126_ SDVKG 131_ TLVTV 136_ TEEPR 141_ VPTIA 146_ SPVEL 151_ LEGTE 156_ VDFNC 161_ STPYV 166_ CLQEQ 171_ VRLQW 176_ QGQDP 181_ ARSVT 186_ FNSQK 191_ FEPTG 196_ VGHLE 201_ TLHMA 206_ MSWQD 211_ HGRIL 216_ RCQLS 221_ VANHR 226_ AQSEI 231_ HLQVK 236_ YAPKG 241_ VKILL 246_ SPSGR 251_ NILPG 256_ ELVTL 261_ TCQVN 266_ SSYPA 271_ VSSIK 276_ WLKDG 281_ VRLQT 286_ KTGVL 291_ HLPQA 296_ AWSDA 301_ GVYTC 306_ QAENG 311_ VGSLV 316_ SPPIS 321_ LHIFM 326_ AEVQV 331_ SPAGP 336_ ILENQ 341_ TVTLV 346_ CNTPN 351_ EAPSD 356_ LRYSW 361_ YKNHV 366_ LLEDA 371_ HSHTL 376_ RLHLA 381_ TRADT 386_ GFYFC 391_ EVQNV 396_ HGSER 401_ SGPVS 406_ VVVNH 411_ PPLTP 416_ VLTAF 421_ LETQA 426_ GLVGI 431_ LHCSV 436_ VSEPL 441_ ATLVL 446_ SHGGH 451_ ILAST 456_ SGDSD 461_ HSPRF 466_ SGTSG 471_ PNSLR 476_ LEIRD 481_ LEETD 486_ SGEYK 491_ CSATN 496_ SLGNA 501_ TSTLD 506_ FHANA 511_ ARLLI 516_ SPAAE 521_ VVEGQ 526_ AVTLS 531_ CRSGL 536_ SPTPD 541_ ARFSW 546_ YLNGA 551_ LLHEG 556_ PGSSL 561_ LLPAA 566_ SSTDA 571_ GSYHC 576_ RARDG 581_ HSASG 586_ PSSPA 591_ VLTVL 596_ YPPRQ 601_ PTFTT 606_ RLDLD 611_ AAGAG 616_ AGRRG 621_ LLLCR 626_ VDSDP 631_ PARLQ 636_ LLHKD 641_ RVVAT 646_ SLPSG 651_ GGCST 656_ CGGCS 661_ PRMKV 666_ TKAPN 671_ LLRVE 676_ IHNPL 681_ LEEEG 686_ LYLCE 691_ ASNAL 696_ GNAST 701_ SATFN 706_ GQATV 711_ LAIAP 716_ SHTLQ 721_ EGTEA 726_ NLTCN 731_ VSREA 736_ AGSPA 741_ NFSWF 746_ RNGVL 751_ WAQGP 756_ LETVT 761_ LLPVA 766_ RTDAA 771_ LYACR 776_ ILTEA 781_ GAQLS 786_ TPVLL 791_ SVLYP 796_ PDRPK 801_ LSALL 806_ DMGQG 811_ HMALF 816_ ICTVD 821_ SRPLA 826_ LLALF 831_ HGEHL 836_ LATSL 841_ GPQVP 846_ SHGRF 851_ QAKAE 856_ ANSLK 861_ LEVRE 866_ LGLGD 871_ SGSYR 876_ CEATN 881_ VLGSS 886_ NTSLF 891_ FQVRG 896_ AWVQV 901_ SPSPE 906_ LQEGQ 911_ AVVLS 916_ CQVHT 921_ GVPEG 926_ TSYRW 931_ YRDGQ 936_ PLQES 941_ TSATL 946_ RFAAI 951_ TLTQA 956_ GAYHC 961_ QAQAP 966_ GSATT 971_ SLAAP 976_ ISLHV 981_ SYAPR 986_ HVTLT 991_ TLMDT 996_ GPGRL 1001_ GLLLC 1006_ RVDSD 1011_ PPAQL 1016_ RLLHG 1021_ DRLVA 1026_ STLQG 1031_ VGGPE 1036_ GSSPR 1041_ LHVAV 1046_ APNTL 1051_ RLEIH 1056_ GAMLE 1061_ DEGVY 1066_ ICEAS 1071_ NTLGQ 1076_ ASASA 1081_ DFDAQ 1086_ AVNVQ 1091_ VWPGA 1096_ TVREG 1101_ QLVNL 1106_ TCLVW 1111_ TTHPA 1116_ QLTYT 1121_ WYQDG 1126_ QQRLD 1131_ AHSIP 1136_ LPNVT 1141_ VRDAT 1146_ SYRCG 1151_ VGPPG 1156_ RAPRL 1161_ SRPIT 1166_ LDVLY 1171_ APRNL 1176_ RLTYL 1181_ LESHG 1186_ GQLAL 1191_ VLCTV 1196_ DSRPP 1201_ AQLAL 1206_ SHAGR 1211_ LLASS 1216_ TAASV 1221_ PNTLR 1226_ LELRG 1231_ PQPRD 1236_ EGFYS 1241_ CSARS 1246_ PLGQA 1251_ NTSLE 1256_ LRLEG 1261_ VRVIL 1266_ APEAA 1271_ VPEGA 1276_ PITVT 1281_ CADPA 1286_ AHAPT 1291_ LYTWY 1296_ HNGRW 1301_ LQEGP 1306_ AASLS 1311_ FLVAT 1316_ RAHAG 1321_ AYSCQ 1326_ AQDAQ 1331_ GTRSS 1336_ RPAAL 1341_ QVLYA 1346_ PQDAV 1351_ LSSFR 1356_ DSRAR 1361_ SMAVI 1366_ QCTVD 1371_ SEPPA 1376_ ELALS 1381_ HDGKV 1386_ LATSS 1391_ GVHSL 1396_ ASGTG 1401_ HVQVA 1406_ RNALR 1411_ LQVQD 1416_ VPAGD 1421_ DTYVC 1426_ TAQNL 1431_ LGSIS 1436_ TIGRL 1441_ QVEGA 1446_ RVVAE 1451_ PGLDV 1456_ PEGAA 1461_ LNLSC 1466_ RLLGG 1471_ PGPVG 1476_ NSTFA 1481_ WFWND 1486_ RRLHA 1491_ EPVPT 1496_ LAFTH 1501_ VARAQ 1506_ AGMYH 1511_ CLAEL 1516_ PTGAA 1521_ ASAPV 1526_ MLRVL 1531_ YPPKT 1536_ PTMMV 1541_ FVEPE 1546_ GGLRG 1551_ ILDCR 1556_ VDSEP 1561_ LASLT 1566_ LHLGS 1571_ RLVAS 1576_ SQPQG 1581_ APAEP 1586_ HIHVL 1591_ ASPNA 1596_ LRVDI 1601_ EALRP 1606_ SDQGE 1611_ YICSA 1616_ SNVLG 1621_ SASTS 1626_ TYFGV 1631_ RALHR 1636_ LHQFQ 1641_ QLLWV 1646_ LGLLV 1651_ GLLLL 1656_ LLGLG 1661_ ACYTW 1666_ RRRRV 1671_ CKQSM 1676_ GENSV 1681_ EMAFQ 1686_ KETTQ 1691_ LIDPD 1696_ AATCE 1701_TSTCA
1: Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed:12940982, PubMed:33489013). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed:28129379). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 (PubMed:28129379, PubMed:34782760). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (PubMed:12940982). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (PubMed:26358190)
2: (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane