Protein sprouty homolog 4 (Spry-4)
1_MEPPI 6_ PQSAP 11_ LTPNS 16_ VMVQP 21_ LLDSR 26_ MSHSR 31_ LQHPL 36_ TILPI 41_ DQVKT 46_ SHVEN 51_ DYIDN 56_ PSLAL 61_ TTGPK 66_ RTRGG 71_ APELA 76_ PTPAR 81_ CDQDV 86_ THHWI 91_ SFSGR 96_ PSSVS 101_ SSSST 106_ SSDQR 111_ LLDHM 116_ APPPV 121_ ADQAS 126_ PRAVR 131_ IQPKV 136_ VHCQP 141_ LDLKG 146_ PAVPP 151_ ELDKH 156_ FLLCE 161_ ACGKC 166_ KCKEC 171_ ASPRT 176_ LPSCW 181_ VCNQE 186_ CLCSA 191_ QTLVN 196_ YGTCM 201_ CLVQG 206_ IFYHC 211_ TNEDD 216_ EGSCA 221_ DHPCS 226_ CSRSN 231_ CCARW 236_ SFMGA 241_ LSVVL 246_ PCLLC 251_ YLPAT 256_ GCVKL 261_ AQRGY 266_ DRLRR 271_ PGCRC 276_ KHTNS 281_ VICKA 286_ ASGDA 291_KTSRP
1: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898)