Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)
1_MEPEQ 6_ MLEGQ 11_ TQVAE 16_ NPHSE 21_ YGLTD 26_ NVERI 31_ VENEK 36_ INAEK 41_ SSKQK 46_ VDLQS 51_ LPTRA 56_ YLDQT 61_ VVPIL 66_ LQGLA 71_ VLAKE 76_ RPPNP 81_ IEFLA 86_ SYLLK 91_NKAQF
1: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport