Tripartite motif-containing protein 15 (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7)
1_MPATP 6_ SLKVV 11_ HELPA 16_ CTLCA 21_ GPLED 26_ AVTIP 31_ CGHTF 36_ CRLCL 41_ PALSQ 46_ MGAQS 51_ SGKIL 56_ LCPLC 61_ QEEEQ 66_ AETPM 71_ APVPL 76_ GPLGE 81_ TYCEE 86_ HGEKI 91_ YFFCE 96_ NDAEF 101_ LCVFC 106_ REGPT 111_ HQAHT 116_ VGFLD 121_ EAIQP 126_ YRDRL 131_ RSRLE 136_ ALSTE 141_ RDEIE 146_ DVKCQ 151_ EDQKL 156_ QVLLT 161_ QIESK 166_ KHQVE 171_ TAFER 176_ LQQEL 181_ EQQRC 186_ LLLAR 191_ LRELE 196_ QQIWK 201_ ERDEY 206_ ITKVS 211_ EEVTR 216_ LGAQV 221_ KELEE 226_ KCQQP 231_ ASELL 236_ QDVRV 241_ NQSRC 246_ EMKTF 251_ VSPEA 256_ ISPDL 261_ VKKIR 266_ DFHRK 271_ ILTLP 276_ EMMRM 281_ FSENL 286_ AHHLE 291_ IDSGV 296_ ITLDP 301_ QTASR 306_ SLVLS 311_ EDRKS 316_ VRYTR 321_ QKKSL 326_ PDSPL 331_ RFDGL 336_ PAVLG 341_ FPGFS 346_ SGRHR 351_ WQVDL 356_ QLGDG 361_ GGCTV 366_ GVAGE 371_ GVRRK 376_ GEMGL 381_ SAEDG 386_ VWAVI 391_ ISHQQ 396_ CWAST 401_ SPGTD 406_ LPLSE 411_ IPRGV 416_ RVALD 421_ YEAGQ 426_ VTLHN 431_ AQTQE 436_ PIFTF 441_ TASFS 446_ GKVFP 451_ FFAVW 456_KKGSC
1: E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:23077300, PubMed:34142270). Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). Also plays a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296). Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300). Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740). Also plays an important regulatory effect on the activation of hepatic stellate cells (HSCs)