E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27) (Glycogenin-interacting protein) (RING finger protein 90) (Tripartite motif-containing protein 7)
1_MAAVG 6_ PRTGP 11_ GTGAE 16_ ALALA 21_ AELQG 26_ EATCS 31_ ICLEL 36_ FREPV 41_ SVECG 46_ HSFCR 51_ ACIGR 56_ CWERP 61_ GAGSV 66_ GAATR 71_ APPFP 76_ LPCPQ 81_ CREPA 86_ RPSQL 91_ RPNRQ 96_ LAAVA 101_ TLLRR 106_ FSLPA 111_ AAPGE 116_ HGSQA 121_ AAARA 126_ AAARC 131_ GQHGE 136_ PFKLY 141_ CQDDG 146_ RAICV 151_ VCDRA 156_ REHRE 161_ HAVLP 166_ LDEAV 171_ QEAKE 176_ LLESR 181_ LRVLK 186_ KELED 191_ CEVFR 196_ STEKK 201_ ESKEL 206_ LKQMA 211_ AEQEK 216_ VGAEF 221_ QALRA 226_ FLVEQ 231_ EGRLL 236_ GRLEE 241_ LSREV 246_ AQKQN 251_ ENLAQ 256_ LGVEI 261_ TQLSK 266_ LSSQI 271_ QETAQ 276_ KPDLD 281_ FLQEF 286_ KSTLS 291_ RCSNV 296_ PGPKP 301_ TTVSS 306_ EMKNK 311_ VWNVS 316_ LKTFV 321_ LKGML 326_ KKFKE 331_ DLRGE 336_ LEKEE 341_ KVELT 346_ LDPDT 351_ ANPRL 356_ ILSLD 361_ LKGVR 366_ LGERA 371_ QDLPN 376_ HPCRF 381_ DTNTR 386_ VLASC 391_ GFSSG 396_ RHHWE 401_ VEVGS 406_ KDGWA 411_ FGVAR 416_ ESVRR 421_ KGLTP 426_ FTPEE 431_ GVWAL 436_ QLNGG 441_ QYWAV 446_ TSPER 451_ SPLSC 456_ GHLSR 461_ VRVAL 466_ DLEVG 471_ AVSFY 476_ AVEDM 481_ RHLYT 486_ FRVNF 491_ QERVF 496_ PLFSV 501_ CSTGT 506_YLRIW
1: E3 ubiquitin-protein ligase that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration (PubMed:25851810, PubMed:32853985, PubMed:34062120). Acts as an antiviral effector against multiple viruses by targeting specific viral proteins for ubiquitination and degradation including norovirus NTPase protein or SARS-CoV-2 NSP5 and NSP8 proteins (PubMed:34062120, PubMed:35982226). Mechanistically, recognizes the C-terminal glutamine-containing motif usually generated by viral proteases that process the polyproteins and trigger their ubiquitination and subsequent degradation (PubMed:35867826, PubMed:35893676, PubMed:35982226). Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of pro-inflammatory cytokines and type I interferon (By similarity). Also plays a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). Mediates the ubiquitination of the SIN3-HDAC chromatin remodeling complex component BRMS1 (PubMed:32853985). Modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells by ubiquitinating NCOA4, leading to its degradation (PubMed:36067704)
2: (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination