Tripartite motif-containing protein 6 (EC 2.3.2.27) (RING finger protein 89) (RING-type E3 ubiquitin transferase TRIM6)
1_MTSPV 6_ LVDIR 11_ EEVTC 16_ PICLE 21_ LLTEP 26_ LSIDC 31_ GHSFC 36_ QACIT 41_ PNGRE 46_ SVIGQ 51_ EGERS 56_ CPVCQ 61_ TSYQP 66_ GNLRP 71_ NRHLA 76_ NIVRR 81_ LREVV 86_ LGPGK 91_ QLKAV 96_ LCADH 101_ GEKLQ 106_ LFCQE 111_ DGKVI 116_ CWLCE 121_ RSQEH 126_ RGHHT 131_ FLVEE 136_ VAQEY 141_ QEKFQ 146_ ESLKK 151_ LKNEE 156_ QEAEK 161_ LTAFI 166_ REKKT 171_ SWKNQ 176_ MEPER 181_ CRIQT 186_ EFNQL 191_ RNILD 196_ RVEQR 201_ ELKKL 206_ EQEEK 211_ KGLRI 216_ IEEAE 221_ NDLVH 226_ QTQSL 231_ RELIS 236_ DLERR 241_ CQGST 246_ MELLQ 251_ DVSDV 256_ TERSE 261_ FWTLR 266_ KPEAL 271_ PTKLR 276_ SMFRA 281_ PDLKR 286_ MLRVC 291_ RELTD 296_ VQSYW 301_ VDVTL 306_ NPHTA 311_ NLNLV 316_ LAKNR 321_ RQVRF 326_ VGAKV 331_ SGPSC 336_ LEKHY 341_ DCSVL 346_ GSQHF 351_ SSGKH 356_ YWEVD 361_ VAKKT 366_ AWILG 371_ VCSNS 376_ LGPTF 381_ SFNHF 386_ AQNHS 391_ AYSRY 396_ QPQSG 401_ YWVIG 406_ LQHNH 411_ EYRAY 416_ EDSSP 421_ SLLLS 426_ MTVPP 431_ RRVGV 436_ FLDYE 441_ AGTVS 446_ FYNVT 451_ NHGFP 456_ IYTFS 461_ KYYFP 466_ TTLCP 471_ YFNPC 476_ NCVIP 481_MTLRR
1: E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218, PubMed:31694946). In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218). Also ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhanced RIGI-mediated innate antiviral immune response (PubMed:35263596)
2: (Microbial infection) Ubiquitinates ebolavirus protein VP35 leading to enhanced viral transcriptase activity