Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
1_MASGI 6_ LVNVK 11_ EEVTC 16_ PICLE 21_ LLTQP 26_ LSLDC 31_ GHSFC 36_ QACLT 41_ ANHKK 46_ SMLDK 51_ GESSC 56_ PVCRI 61_ SYQPE 66_ NIRPN 71_ RHVAN 76_ IVEKL 81_ REVKL 86_ SPEGQ 91_ KVDHC 96_ ARHGE 101_ KLLLF 106_ CQEDG 111_ KVICW 116_ LCERS 121_ QEHRG 126_ HHTFL 131_ TEEVA 136_ REYQV 141_ KLQAA 146_ LEMLR 151_ QKQQE 156_ AEELE 161_ ADIRE 166_ EKASW 171_ KTQIQ 176_ YDKTN 181_ VLADF 186_ EQLRD 191_ ILDWE 196_ ESNEL 201_ QNLEK 206_ EEEDI 211_ LKSLT 216_ NSETE 221_ MVQQT 226_ QSLRE 231_ LISDL 236_ EHRLQ 241_ GSVME 246_ LLQGV 251_ DGVIK 256_ RTENV 261_ TLKKP 266_ ETFPK 271_ NQRRV 276_ FRAPD 281_ LKGML 286_ EVFRE 291_ LTDVR 296_ RYWVD 301_ VTVAP 306_ NNISC 311_ AVISE 316_ DKRQV 321_ SSPKP 326_ QIIYG 331_ ARGTR 336_ YQTFV 341_ NFNYC 346_ TGILG 351_ SQSIT 356_ SGKHY 361_ WEVDV 366_ SKKTA 371_ WILGV 376_ CAGFQ 381_ PDAMC 386_ NIEKN 391_ ENYQP 396_ KYGYW 401_ VIGLE 406_ EGVKC 411_ SAFQD 416_ SSFHT 421_ PSVPF 426_ IVPLS 431_ VIICP 436_ DRVGV 441_ FLDYE 446_ ACTVS 451_ FFNIT 456_ NHGFL 461_ IYKFS 466_ HCSFS 471_ QPVFP 476_ YLNPR 481_ KCGVP 486_MTLCS
1: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057)