E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4)
1_MEAED 6_ IQEEL 11_ TCPIC 16_ LDYFQ 21_ DPVSI 26_ ECGHN 31_ FCRGC 36_ LHRNW 41_ APGGG 46_ PFPCP 51_ ECRHP 56_ SAPAA 61_ LRPNW 66_ ALARL 71_ TEKTQ 76_ RRRLG 81_ PVPPG 86_ LCGRH 91_ WEPLR 96_ LFCED 101_ DQRPV 106_ CLVCR 111_ ESQEH 116_ QTHAM 121_ APIDE 126_ AFESY 131_ RTGNF 136_ DIHVD 141_ EWKRR 146_ LIRLL 151_ LYHFK 156_ QEEKL 161_ LKSQR 166_ NLVAK 171_ MKKVM 176_ HLQDV 181_ EVKNA 186_ TQWKD 191_ KIKSQ 196_ RMRIS 201_ TEFSK 206_ LHNFL 211_ VEEED 216_ LFLQR 221_ LNKEE 226_ EETKK 231_ KLNEN 236_ TLKLN 241_ QTIAS 246_ LKKLI 251_ LEVGE 256_ KSQAP 261_ TLELL 266_ QNPKE 271_ VLTRS 276_ EIQDV 281_ NYSLE 286_ AVKVK 291_ TVCQI 296_ PLMKE 301_ MLKRF 306_ QVAVN 311_ LAEDT 316_ AHPKL 321_ VFSQE 326_ GRYVK 331_ NTASA 336_ SSWPV 341_ FSSAW 346_ NYFAG 351_ WRNPQ 356_ KTAFV 361_ ERFQH 366_ LPCVL 371_ GKNVF 376_ TSGKH 381_ YWEVE 386_ SRDSL 391_ EVAVG 396_ VCRED 401_ VMGIT 406_ DRSKM 411_ SPDVG 416_ IWAIY 421_ WSAAG 426_ YWPLI 431_ GFPGT 436_ PTQQE 441_ PALHR 446_ VGVYL 451_ DRGTG 456_ NVSFY 461_ SAVDG 466_ VHLHT 471_ FSCSS 476_ VSRLR 481_ PFFWL 486_ SPLAS 491_LVIPP
1: E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor RIGI, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction