Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2)
1_MASEG 6_ TNIPS 11_ PVVRQ 16_ IDKQF 21_ LICSI 26_ CLERY 31_ KNPKV 36_ LPCLH 41_ TFCER 46_ CLQNY 51_ IPAHS 56_ LTLSC 61_ PVCRQ 66_ TSILP 71_ EKGVA 76_ ALQNN 81_ FFITN 86_ LMDVL 91_ QRTPG 96_ SNAEE 101_ SSILE 106_ TVTAV 111_ AAGKP 116_ LSCPN 121_ HDGNV 126_ MEFYC 131_ QSCET 136_ AMCRE 141_ CTEGE 146_ HAEHP 151_ TVPLK 156_ DVVEQ 161_ HKASL 166_ QVQLD 171_ AVNKR 176_ LPEID 181_ SALQF 186_ ISEII 191_ HQLTN 196_ QKASI 201_ VDDIH 206_ STFDE 211_ LQKTL 216_ NVRKS 221_ VLLME 226_ LEVNY 231_ GLKHK 236_ VLQSQ 241_ LDTLL 246_ QGQES 251_ IKSCS 256_ NFTAQ 261_ ALNHG 266_ TETEV 271_ LLVKK 276_ QMSEK 281_ LNELA 286_ DQDFP 291_ LHPRE 296_ NDQLD 301_ FIVET 306_ EGLKK 311_ SIHNL 316_ GTILT 321_ TNAVA 326_ SETVA 331_ TGEGL 336_ RQTII 341_ GQPMS 346_ VTITT 351_ KDKDG 356_ ELCKT 361_ GNAYL 366_ TAELS 371_ TPDGS 376_ VADGE 381_ ILDNK 386_ NGTYE 391_ FLYTV 396_ QKEGD 401_ FTLSL 406_ RLYDQ 411_ HIRGS 416_ PFKLK 421_ VIRSA 426_ DVSPT 431_ TEGVK 436_ RRVKS 441_ PGSGH 446_ VKQKA 451_ VKRPA 456_ SMYST 461_ GKRKE 466_ NPIED 471_ DLIFR 476_ VGTKG 481_ RNKGE 486_ FTNLQ 491_ GVAAS 496_ TNGKI 501_ LIADS 506_ NNQCV 511_ QIFSN 516_ DGQFK 521_ SRFGI 526_ RGRSP 531_ GQLQR 536_ PTGVA 541_ VHPSG 546_ DIIIA 551_ DYDNK 556_ WVSIF 561_ SSDGK 566_ FKTKI 571_ GSGKL 576_ MGPKG 581_ VSVDR 586_ NGHII 591_ VVDNK 596_ ACCVF 601_ IFQPN 606_ GKIVT 611_ RFGSR 616_ GNGDR 621_ QFAGP 626_ HFAAV 631_ NSNNE 636_ IIITD 641_ FHNHS 646_ VKVFN 651_ QEGEF 656_ MLKFG 661_ SNGEG 666_ NGQFN 671_ APTGV 676_ AVDSN 681_ GNIIV 686_ ADWGN 691_ SRIQV 696_ FDGSG 701_ SFLSY 706_ INTSA 711_ DPLYG 716_ PQGLA 721_ LTSDG 726_ HVVVA 731_ DSGNH 736_CFKVY
1: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738)