Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-)
1_MKRTP 6_ TAEER 11_ EREAK 16_ KLRLL 21_ EELED 26_ TWLPY 31_ LTPKD 36_ DEFYQ 41_ QWQLK 46_ YPKLI 51_ LREAS 56_ SVSEE 61_ LHKEV 66_ QEAFL 71_ TLHKH 76_ GCLFR 81_ DLVRI 86_ QGKDL 91_ LTPVS 96_ RILIG 101_ NPGCT 106_ YKYLN 111_ TRLFT 116_ VPWPV 121_ KGSNI 126_ KHTEA 131_ EIAAA 136_ CETFL 141_ KLNDY 146_ LQIET 151_ IQALE 156_ ELAAK 161_ EKANE 166_ DAVPL 171_ CMSAD 176_ FPRVG 181_ MGSSY 186_ NGQDE 191_ VDIKS 196_ RAAYN 201_ VTLLN 206_ FMDPQ 211_ KMPYL 216_ KEEPY 221_ FGMGK 226_ MAVSW 231_ HHDEN 236_ LVDRS 241_ AVAVY 246_ SYSCE 251_ GPEEE 256_ SEDDS 261_ HLEGR 266_ DPDIW 271_ HVGFK 276_ ISWDI 281_ ETPGL 286_ AIPLH 291_ QGDCY 296_ FMLDD 301_ LNATH 306_ QHCVL 311_ AGSQP 316_ RFSST 321_ HRVAE 326_ CSTGT 331_ LDYIL 336_ QRCQL 341_ ALQNV 346_ CDDVD 351_ NDDVS 356_ LKSFE 361_ PAVLK 366_ QGEEI 371_ HNEVE 376_ FEWLR 381_ QFWFQ 386_ GNRYR 391_ KCTDW 396_ WCQPM 401_ AQLEA 406_ LWKKM 411_ EGVTN 416_ AVLHE 421_ VKREG 426_ LPVEQ 431_ RNEIL 436_ TAILA 441_ SLTAR 446_ QNLRR 451_ EWHAR 456_ CQSRI 461_ ARTLP 466_ ADQKP 471_ ECRPY 476_ WEKDD 481_ ASMPL 486_ PFDLT 491_ DIVSE 496_LRGQL
1: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:30197295). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359)