Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)
1_MPAES 6_ GKRFK 11_ PSKYV 16_ PVSAA 21_ AIFLV 26_ GATTL 31_ FFAFT 36_ CPGLS 41_ LYVSP 46_ AVPIY 51_ NAIMF 56_ LFVLA 61_ NFSMA 66_ TFMDP 71_ GIFPR 76_ AEEDE 81_ DKEDD 86_ FRAPL 91_ YKTVE 96_ IKGIQ 101_ VRMKW 106_ CATCR 111_ FYRPP 116_ RCSHC 121_ SVCDN 126_ CVEEF 131_ DHHCP 136_ WVNNC 141_ IGRRN 146_ YRYFF 151_ LFLLS 156_ LTAHI 161_ MGVFG 166_ FGLLY 171_ VLYHI 176_ EELSG 181_ VRTAV 186_ TMAVM 191_ CVAGL 196_ FFIPV 201_ AGLTG 206_ FHVVL 211_ VARGR 216_ TTNEQ 221_ VTGKF 226_ RGGVN 231_ PFTNG 236_ CCNNV 241_ SRVLC 246_ SSPAP 251_ RYLGR 256_ PKKEK 261_ TIVIR 266_ PPFLR 271_ PEVSD 276_ GQITV 281_ KIMDN 286_ GIQGE 291_ LRRTK 296_ SKGSL 301_ EITES 306_ QSADA 311_ EPPPP 316_ PKPDL 321_ SRYTG 326_ LRTHL 331_ GLATN 336_ EDSSL 341_ LAKDS 346_ PPTPT 351_ MYKYR 356_ PGYSS 361_ SSTSA 366_ AMPHS 371_ SSAKL 376_ SRGDS 381_ LKEPT 386_ SIAES 391_ SRHPS 396_ YRSEP 401_ SLEPE 406_ SFRSP 411_ TFGKS 416_ FHFDP 421_ LSSGS 426_ RSSSL 431_ KSAQG 436_ TGFEL 441_ GQLQS 446_ IRSEG 451_ TTSTS 456_ YKSLA 461_ NQTRN 466_ GSLSY 471_ DSLLT 476_ PSDSP 481_ DFESV 486_ QAGPE 491_ PDPPL 496_ GYTSP 501_ FLSAR 506_ LAQQR 511_ EAERH 516_ PRLVP 521_ TGPTH 526_ REPSP 531_ VRYDN 536_ LSRHI 541_ VASLQ 546_ EREKL 551_ LRQSP 556_ PLPGR 561_ EEEPG 566_ LGDSG 571_ IQSTP 576_ GSGHA 581_ PRTSS 586_ SSDDS 591_ KRSPL 596_ GKTPL 601_ GRPAV 606_ PRFGK 611_ PDGLR 616_ GRGVG 621_ SPEPG 626_ PTAPY 631_ LGRSM 636_ SYSSQ 641_ KAQPG 646_ VSETE 651_ EVALQ 656_ PLLTP 661_ KDEVQ 666_ LKTTY 671_ SKSNG 676_ QPKSL 681_ GSASP 686_ GPGQP 691_ PLSSP 696_ TRGGV 701_ KKVSG 706_VGGTT
1: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239)