CLOCK-interacting pacemaker (CLOCK-interacting circadian protein)
1_MERKN 6_ PSRES 11_ PRRLS 16_ AKVGK 21_ GTEMK 26_ KVARQ 31_ LGMAA 36_ AESDK 41_ DSGFS 46_ DGSSE 51_ CLSSA 56_ EQMES 61_ EDMLS 66_ ALGWS 71_ REDRP 76_ RQNSK 81_ TAKNA 86_ FPTLS 91_ PMVVM 96_ KNVLV 101_ KQGSS 106_ SSQLQ 111_ SWTVQ 116_ PSFEV 121_ ISAQP 126_ QLLFL 131_ HPPVP 136_ SPVSP 141_ CHTGE 146_ KKSDS 151_ RNYLP 156_ ILNSY 161_ TKIAP 166_ HPGKR 171_ GLSLG 176_ PEEKG 181_ TSGVQ 186_ KKICT 191_ ERLGP 196_ SLSSS 201_ EPTKA 206_ GAVPS 211_ SPSTP 216_ APPSA 221_ KLAED 226_ SALQG 231_ VPSLV 236_ AGGSP 241_ QTLQP 246_ VSSSH 251_ VAKAP 256_ SLTFA 261_ SPASP 266_ VCASD 271_ STLHG 276_ LESNS 281_ PLSPL 286_ SANYS 291_ SPLWA 296_ AEHLC 301_ RSPDI 306_ FSEQR 311_ QSKHR 316_ RFQNT 321_ LVVLH 326_ KSGLL 331_ EITLK 336_ TKELI 341_ RQNQA 346_ TQVEL 351_ DQLKE 356_ QTQLF 361_ IEATK 366_ SRAPQ 371_ AWAKL 376_ QASLT 381_ PGSSN 386_ TGSDL 391_EAFSD
1: Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock