(E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O)
1_MADPA 6_ APTPA 11_ APAPA 16_ QAPAP 21_ APEAV 26_ PAPAA 31_ APVPA 36_ PAPAS 41_ DSASG 46_ PSSDS 51_ GPEAG 56_ SQRLL 61_ FSHDL 66_ VSGRY 71_ RGSVH 76_ FGLVR 81_ LIHGE 86_ DSDSE 91_ GEEEG 96_ RGSSG 101_ CSEAG 106_ GAGHE 111_ EGRAS 116_ PLRRG 121_ YVRVQ 126_ WYPEG 131_ VKQHV 136_ KETKL 141_ KLEDR 146_ SVVPR 151_ DVVRH 156_ MRSTD 161_ SQCGT 166_ VIDVN 171_ IDCAV 176_ KLIGT 181_ NCIIY 186_ PVNSK 191_ DLQHI 196_ WPFMY 201_ GDYIA 206_ YDCWL 211_ GKVYD 216_ LKNQI 221_ ILKLS 226_ NGARC 231_ SMNTE 236_ DGAKL 241_ YDVCP 246_ HVSDS 251_ GLFFD 256_ DSYGF 261_ YPGQV 266_ LIGPA 271_ KIFSS 276_ VQWLS 281_ GVKPV 286_ LSTKS 291_ KFRVV 296_ VEEVQ 301_ VVELK 306_ VTWIT 311_ KSFCP 316_ GGTDS 321_ VSPPP 326_ SVITQ 331_ ENLGR 336_ VKRLG 341_ CFDHA 346_ QRQLG 351_ ERCLY 356_ VFPAK 361_ VEPAK 366_ IAWEC 371_ PEKNC 376_ AQGEG 381_ SMAKK 386_ VKRLL 391_ KKQVV 396_ RIMSC 401_ SPDTQ 406_ CSRDH 411_ SMEDP 416_ DKKGE 421_ SKTKS 426_ EAESA 431_ SPEET 436_ PDGSA 441_ SPVEM 446_ QDEGA 451_ EEPHE 456_ AGEQL 461_ PPFLL 466_ KEGRD 471_ DRLHS 476_ AEQDA 481_ DDEAA 486_ DDTDD 491_ TSSVT 496_ SSASS 501_ TTSSQ 506_ SGSGT 511_ SRKKS 516_ IPLSI 521_ KNLKR 526_ KHKRK 531_ KNKIT 536_ RDFKP 541_ GDRVA 546_ VEVVT 551_ TMTSA 556_ DVMWQ 561_ DGSVE 566_ CNIRS 571_ NDLFP 576_ VHHLD 581_ NNEFC 586_ PGDFV 591_ VDKRV 596_ QSCPD 601_ PAVYG 606_ VVQSG 611_ DHIGR 616_ TCMVK 621_ WFKLR 626_ PSGDD 631_ VELIG 636_ EEEDV 641_ SVYDI 646_ ADHPD 651_ FRFRT 656_ TDIVI 661_ RIGNT 666_ EDGAP 671_ HKEDE 676_ PSVGQ 681_ VARVD 686_ VSSKV 691_ EVVWA 696_ DNSKT 701_ IILPQ 706_ HLYNI 711_ ESEIE 716_ ESDYD 721_ SVEGS 726_ TSGAS 731_ SDEWE 736_ DDSDS 741_ WETDN 746_ GLVED 751_ EHPKI 756_ EEPPI 761_ PPLEQ 766_ PVAPE 771_ DKGVV 776_ ISEEA 781_ ATAAV 786_ QGAVA 791_ MAAPM 796_ AGLME 801_ KAGKD 806_ GPPKS 811_ FRELK 816_ EAIKI 821_ LESLK 826_ NMTVE 831_ QLLTG 836_ SPTSP 841_ TVEPE 846_ KPTRE 851_ KKFLD 856_ DIKKL 861_ QENLK 866_ KTLDN 871_ VAIVE 876_ EEKME 881_ AVPDV 886_ ERKED 891_ KPEGQ 896_ SPVKA 901_ EWPSE 906_ TPVLC 911_ QQCGG 916_ KPGVT 921_ FTSAK 926_ GEVFS 931_ VLEFA 936_ PSNHS 941_ FKKIE 946_ FQPPE 951_ AKKFF 956_ STVRK 961_ EMALL 966_ ATSLP 971_ EGIMV 976_ KTFED 981_ RMDLF 986_ SALIK 991_ GPTRT 996_ PYEDG 1001_ LYLFD 1006_ IQLPN 1011_ IYPAV 1016_ PPHFC 1021_ YLSQC 1026_ SGRLN 1031_ PNLYD 1036_ NGKVC 1041_ VSLLG 1046_ TWIGK 1051_ GTERW 1056_ TSKSS 1061_ LLQVL 1066_ ISIQG 1071_ LILVN 1076_ EPYYN 1081_ EAGFD 1086_ SDRGL 1091_ QEGYE 1096_ NSRCY 1101_ NEMAL 1106_ IRVVQ 1111_ SMTQL 1116_ VRRPP 1121_ EVFEQ 1126_ EIRQH 1131_ FSTGG 1136_ WRLVN 1141_ RIESW 1146_ LETHA 1151_ LLEKA 1156_ QALPN 1161_ GVPKA 1166_ SSSPE 1171_ PPAVA 1176_ ELSDS 1181_ GQQEP 1186_ EDGGP 1191_ APGEA 1196_ SQGSD 1201_ SEGGA 1206_ QGLAS 1211_ ASRDH 1216_ TDQTS 1221_ ETAPD 1226_ ASVPP 1231_ SVKPK 1236_ KRRKS 1241_ YRSFL 1246_ PEKSG 1251_ YPDIG 1256_ FPLFP 1261_ LSKGF 1266_ IKSIR 1271_ GVLTQ 1276_ FRAAL 1281_ LEAGM 1286_PECTE
1: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853)