Protein zyg-11 homolog B
1_MPEDQ 6_ AGAAM 11_ EEASP 16_ YSLLD 21_ ICLNF 26_ LTTHL 31_ EKFCS 36_ ARQDG 41_ TLCLQ 46_ EPGVF 51_ PQEVA 56_ DRLLR 61_ TMAFH 66_ GLLND 71_ GTVGI 76_ FRGNQ 81_ MRLKR 86_ ACIRK 91_ AKISA 96_ VAFRK 101_ AFCHH 106_ KLVEL 111_ DATGV 116_ NADIT 121_ ITDII 126_ SGLGS 131_ NKWIQ 136_ QNLQC 141_ LVLNS 146_ LTLSL 151_ EDPYE 156_ RCFSR 161_ LSGLR 166_ ALSIT 171_ NVLFY 176_ NEDLA 181_ EVASL 186_ PRLES 191_ LDISN 196_ TSITD 201_ ITALL 206_ ACKDR 211_ LKSLT 216_ MHHLK 221_ CLKMT 226_ TTQIL 231_ DVVRE 236_ LKHLN 241_ HLDIS 246_ DDKQF 251_ TSDIA 256_ LRLLE 261_ QKDIL 266_ PNLVS 271_ LDVSG 276_ RKHVT 281_ DKAVE 286_ AFIQQ 291_ RPSMQ 296_ FVGLL 301_ ATDAG 306_ YSEFL 311_ TGEGH 316_ LKVSG 321_ EANET 326_ QIAEA 331_ LKRYS 336_ ERAFF 341_ VREAL 346_ FHLFS 351_ LTHVM 356_ EKTKP 361_ EILKL 366_ VVTGM 371_ RNHPM 376_ NLPVQ 381_ LAASA 386_ CVFNL 391_ TKQDL 396_ AAGMP 401_ VRLLA 406_ DVTHL 411_ LLKAM 416_ EHFPN 421_ HQQLQ 426_ KNCLL 431_ SLCSD 436_ RILQD 441_ VPFNR 446_ FEAAK 451_ LVMQW 456_ LCNHE 461_ DQNMQ 466_ RMAVA 471_ IISIL 476_ AAKLS 481_ TEQTA 486_ QLGTE 491_ LFIVR 496_ QLLQI 501_ VKQKT 506_ NQNSV 511_ DTTLK 516_ FTLSA 521_ LWNLT 526_ DESPT 531_ TCRHF 536_ IENQG 541_ LELFM 546_ RVLES 551_ FPTES 556_ SIQQK 561_ VLGLL 566_ NNIAE 571_ VQELH 576_ SELMW 581_ KDFID 586_ HISSL 591_ LHSVE 596_ VEVSY 601_ FAAGI 606_ IAHLI 611_ SRGEQ 616_ AWTLS 621_ RSQRN 626_ SLLDD 631_ LHSAI 636_ LKWPT 641_ PECEM 646_ VAYRS 651_ FNPFF 656_ PLLGC 661_ FTTPG 666_ VQLWA 671_ VWAMQ 676_ HVCSK 681_ NPSRY 686_ CSMLI 691_ EEGGL 696_ QHLYN 701_ IKDHE 706_ HTDPH 711_ VQQIA 716_ VAILD 721_ SLEKH 726_ IVRHG 731_ RPPPC 736_KKQPQ
1: Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition elements (PubMed:33093214, PubMed:34214466, PubMed:35636250). Prefers Nt-Gly but also has the capacity to recognize Nt-Ser, -Ala and -Cys (PubMed:36496439). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098). In addition, plays a role in the amplification of cGAS to enhance innate immune response. Mechanistically, strengthens the processes of cGAS binding with dsDNA and assembling oligomers and also accelerates and stabilizes cGAS-DNA condensation, thereby enhancing production of antiviral IFNs and inflammatory cytokines (PubMed:36933219)