Ethanolaminephosphotransferase 1 (hEPT1) (EC 2.7.8.1) (Selenoprotein I) (SelI)
1_MAGYE 6_ YVSPE 11_ QLAGF 16_ DKYKY 21_ SAVDT 26_ NPLSL 31_ YVMHP 36_ FWNTI 41_ VKVFP 46_ TWLAP 51_ NLITF 56_ SGFLL 61_ VVFNF 66_ LLMAY 71_ FDPDF 76_ YASAP 81_ GHKHV 86_ PDWVW 91_ IVVGI 96_ LNFVA 101_ YTLDG 106_ VDGKQ 111_ ARRTN 116_ SSTPL 121_ GELFD 126_ HGLDS 131_ WSCVY 136_ FVVTV 141_ YSIFG 146_ RGSTG 151_ VSVFV 156_ LYLLL 161_ WVVLF 166_ SFILS 171_ HWEKY 176_ NTGIL 181_ FLPWG 186_ YDISQ 191_ VTISF 196_ VYIVT 201_ AVVGV 206_ EAWYE 211_ PFLFN 216_ FLYRD 221_ LFTAM 226_ IIGCA 231_ LCVTL 236_ PMSLL 241_ NFFRS 246_ YKNNT 251_ LKLNS 256_ VYEAM 261_ VPLFS 266_ PCLLF 271_ ILSTA 276_ WILWS 281_ PSDIL 286_ ELHPR 291_ VFYFM 296_ VGTAF 301_ ANSTC 306_ QLIVC 311_ QMSST 316_ RCPTL 321_ NWLLV 326_ PLFLV 331_ VLVVN 336_ LGVAS 341_ YVESI 346_ LLYTL 351_ TTAFT 356_ LAHIH 361_ YGVRV 366_ VKQLS 371_ SHFQI 376_ YPFSL 381_ RKPNS 386_ DULGM 391_EEKNI
1: Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine (PE) from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway (PubMed:17132865, PubMed:28052917, PubMed:29500230). PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes (PubMed:17132865). The enzyme is critical for the synthesis of several PE species and also catalyzes the synthesis of plasmanyl-PE, a lipid required for proper myelination and neurodevelopment, from 1-alkyl-2-acylglycerol (PubMed:29500230)