Exportin-4 (Exp4)
1_MMAAA 6_ LGPPE 11_ VIAQL 16_ ENAAK 21_ VLMAP 26_ PSMVN 31_ NEQRQ 36_ HAEHI 41_ FLSFR 46_ KSKSP 51_ FAVCK 56_ HILET 61_ SKVDY 66_ VLFQA 71_ ATAIM 76_ EAVVR 81_ EWILL 86_ EKGSI 91_ ESLRT 96_ FLLTY 101_ VLQRP 106_ NLQKY 111_ VREQI 116_ LLAVA 121_ VIVKR 126_ GSLDK 131_ SIDCK 136_ SIFHE 141_ VSQLI 146_ SSGNP 151_ TVQTL 156_ ACSIL 161_ TALLS 166_ EFSSS 171_ SKTSN 176_ IGLSM 181_ EFHGN 186_ CKRVF 191_ QEEDL 196_ RQIFM 201_ LTVEV 206_ LQEFS 211_ RRENL 216_ NAQMS 221_ SVFQR 226_ YLALA 231_ NQVLS 236_ WNFLP 241_ PNLGR 246_ HYIAM 251_ FESSQ 256_ NVLLK 261_ PTESW 266_ RETLL 271_ DSRVM 276_ ELFFT 281_ VHRKI 286_ REDSD 291_ MAQDS 296_ LQCLA 301_ QLASL 306_ HGPIF 311_ PDEGS 316_ QVDYL 321_ AHFIE 326_ GLLNT 331_ INGIE 336_ IEDSE 341_ AVGIS 346_ SIISN 351_ LITVF 356_ PRNVL 361_ TAIPS 366_ ELFSS 371_ FVNCL 376_ THLTC 381_ SFGRS 386_ AALEE 391_ VLDKD 396_ DMVYM 401_ EAYDK 406_ LLESW 411_ LTLVQ 416_ DDKHF 421_ HKGFF 426_ TQHAV 431_ QVFNS 436_ YIQCH 441_ LAAPD 446_ GTRNL 451_ TANGV 456_ ASREE 461_ EEISE 466_ LQEDD 471_ RDQFS 476_ DQLAS 481_ VGMLG 486_ RIAAE 491_ HCIPL 496_ LTSLL 501_ EERVT 506_ RLHGQ 511_ LQRHQ 516_ QQLLA 521_ SPGSS 526_ TVDNK 531_ MLDDL 536_ YEDIH 541_ WLILV 546_ TGYLL 551_ ADDTQ 556_ GETPL 561_ IPPEI 566_ MEYSI 571_ KHSSE 576_ VDINT 581_ TLQIL 586_ GSPGE 591_ KASSI 596_ PGYNR 601_ TDSVI 606_ RLLSA 611_ ILRVS 616_ EVESR 621_ AIRAD 626_ LTHLL 631_ SPQMG 636_ KDIVW 641_ FLKRW 646_ AKTYL 651_ LVDEK 656_ LYDQI 661_ SLPFS 666_ TAFGA 671_ DTEGS 676_ QWIIG 681_ YLLQK 686_ VISNL 691_ SVWSS 696_ EQDLA 701_ NDTVQ 706_ LLVTL 711_ VERRE 716_ RANLV 721_ IQCEN 726_ WWNLA 731_ KQFAS 736_ RSPPL 741_ NFLSS 746_ PVQRT 751_ LMKAL 756_ VLGGF 761_ AHMDT 766_ ETKQQ 771_ YWTEV 776_ LQPLQ 781_ QRFLR 786_ VINQE 791_ NFQQM 796_ CQQEE 801_ VKQEI 806_ TATLE 811_ ALCGI 816_ AEATQ 821_ IDNVA 826_ ILFNF 831_ LMDFL 836_ TNCIG 841_ LMEVY 846_ KNTPE 851_ TVNLI 856_ IEVFV 861_ EVAHK 866_ QICYL 871_ GESKA 876_ MNLYE 881_ ACLTL 886_ LQVYS 891_ KNNLG 896_ RQRID 901_ VTAEE 906_ EQYQD 911_ LLLIM 916_ ELLTN 921_ LLSKE 926_ FIDFS 931_ DTDEV 936_ FRGHE 941_ PGQAA 946_ NRSVS 951_ AADVV 956_ LYGVN 961_ LILPL 966_ MSQDL 971_ LKFPT 976_ LCNQY 981_ YKLIT 986_ FICEI 991_ FPEKI 996_ PQLPE 1001_ DLFKS 1006_ LMYSL 1011_ ELGMT 1016_ SMSSE 1021_ VCQLC 1026_ LEALT 1031_ PLAEQ 1036_ CAKAQ 1041_ ETDSP 1046_ LFLAT 1051_ RHFLK 1056_ LVFDM 1061_ LVLQK 1066_ HNTEM 1071_ TTAAG 1076_ EAFYT 1081_ LVCLH 1086_ QAEYS 1091_ ELVET 1096_ LLSSQ 1101_ QDPVI 1106_ YQRLA 1111_ DAFNK 1116_ LTASS 1121_ TPPTL 1126_ DRKQK 1131_ MAFLK 1136_ SLEEF 1141_ MANVG 1146_GLLCV
1: Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (PubMed:10944119, PubMed:16449645, PubMed:26787900). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (PubMed:10944119, PubMed:16449645). Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (PubMed:10944119, PubMed:16449645). XPO4 then return to the nuclear compartment and mediate another round of transport (PubMed:10944119, PubMed:16449645). The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10944119, PubMed:16449645). Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 (PubMed:10944119). Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (PubMed:26787900). Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity)