Putative Polycomb group protein ASXL3 (Additional sex combs-like protein 3)
1_MKDKR 6_ KKKDR 11_ TWAEA 16_ ARLAL 21_ EKHPN 26_ SPMTA 31_ KQILE 36_ VIQKE 41_ GLKET 46_ SGTSP 51_ LACLN 56_ AMLHT 61_ NTRIG 66_ DGTFF 71_ KIPGK 76_ SGLYA 81_ LKKEE 86_ SSCPA 91_ DGTLD 96_ LVCES 101_ ELDGT 106_ DMAEA 111_ NAHGE 116_ ENGVC 121_ SKQVT 126_ DEASS 131_ TRDSS 136_ LTNTA 141_ VQSKL 146_ VSSFQ 151_ QHTKK 156_ ALKQA 161_ LRQQQ 166_ KRRNG 171_ VSMMV 176_ NKTVP 181_ RVVLT 186_ PLKVS 191_ DEQSD 196_ SPSGS 201_ ESKNG 206_ EADSS 211_ DKEMK 216_ HGQKS 221_ PTGKQ 226_ TSQHL 231_ KRLKK 236_ SGLGH 241_ LKWTK 246_ AEDID 251_ IETPG 256_ SILVN 261_ TNLRA 266_ LINKH 271_ TFASL 276_ PQHFQ 281_ QYLLL 286_ LLPEV 291_ DRQMG 296_ SDGIL 301_ RLSTS 306_ ALNNE 311_ FFAYA 316_ AQGWK 321_ QRLAE 326_ GEFTP 331_ EMQLR 336_ IRQEI 341_ EKEKK 346_ TEPWK 351_ EKFFE 356_ RFYGE 361_ KLGMS 366_ REESV 371_ KLTTG 376_ PNNAG 381_ AQSSS 386_ SCGTS 391_ GLPVS 396_ AQTAL 401_ AEQQP 406_ KSMKS 411_ PASPE 416_ PGFCA 421_ TLCPM 426_ VEIPP 431_ KDIMA 436_ ELESE 441_ DILIP 446_ EESVI 451_ QEEIA 456_ EEVET 461_ SICEC 466_ QDENH 471_ KTIPE 476_ FSEEA 481_ ESLTN 486_ SHEEP 491_ QIAPP 496_ EDNLE 501_ SCVMM 506_ NDVLE 511_ TLPHI 516_ EVKIE 521_ GKSES 526_ PQEEM 531_ TVVID 536_ QLEVC 541_ DSLIP 546_ STSSM 551_ THVSD 556_ TEHKE 561_ SETAV 566_ ETSTP 571_ KIKTG 576_ SSSLE 581_ GQFPN 586_ EGIAI 591_ DMELQ 596_ SDPEE 601_ QLSEN 606_ ACISE 611_ TSFSS 616_ ESPEG 621_ ACTSL 626_ PSPGG 631_ ETQST 636_ SEESC 641_ TPASL 646_ ETTFC 651_ SEVSS 656_ TENTD 661_ KYNQR 666_ NSTDE 671_ NFHAS 676_ LMSEI 681_ SPIST 686_ SPEIS 691_ EASLM 696_ SNLPL 701_ TSEAS 706_ PVSNL 711_ PLTSE 716_ TSPMS 721_ DLPLT 726_ SETSS 731_ VSSML 736_ LTSET 741_ TFVSS 746_ LPLPS 751_ ETSPI 756_ SNSSI 761_ NERMA 766_ HQQRK 771_ SPSVS 776_ EEPLS 781_ PQKDE 786_ SSATA 791_ KPLGE 796_ NLTSQ 801_ QKNLS 806_ NTPEP 811_ IIMSS 816_ SSIAP 821_ EAFPS 826_ EDLHN 831_ KTLSQ 836_ QTCKS 841_ HVDTE 846_ KPYPA 851_ SIPEL 856_ ASTEM 861_ IKVKN 866_ HSVLQ 871_ RTEKK 876_ VLPSP 881_ LELSV 886_ FSEGT 891_ DNKGN 896_ ELPSA 901_ KLQDK 906_ QYISS 911_ VDKAP 916_ FSEGS 921_ RNKTH 926_ KQGST 931_ QSRLE 936_ TSHTS 941_ KSSEP 946_ SKSPD 951_ GIRNE 956_ SRDSE 961_ ISKRK 966_ TAEQH 971_ SFGIC 976_ KEKRA 981_ RIEDD 986_ QSTRN 991_ ISSSS 996_ PPEKE 1001_ QPPRE 1006_ EPRVP 1011_ PLKIQ 1016_ LSKIG 1021_ PPFII 1026_ KSQPV 1031_ SKPES 1036_ RASTS 1041_ TSVSG 1046_ GRNTG 1051_ ARTLA 1056_ DIKAR 1061_ AQQAR 1066_ AQREA 1071_ AAAAA 1076_ VAAAA 1081_ SIVSG 1086_ AMGSP 1091_ GEGGK 1096_ TRTLA 1101_ HIKEQ 1106_ TKAKL 1111_ FAKHQ 1116_ ARAHL 1121_ FQTSK 1126_ ETRLP 1131_ PPLSS 1136_ KEGPP 1141_ NLEVS 1146_ STPET 1151_ KMEGS 1156_ TGVII 1161_ VNPNC 1166_ RSPSN 1171_ KSAHL 1176_ RETTT 1181_ VLQQS 1186_ LNPSK 1191_ LPETA 1196_ TDLSV 1201_ HSSDE 1206_ NIPVS 1211_ HLSEK 1216_ IVSST 1221_ SSENS 1226_ SVPML 1231_ FNKNS 1236_ VPVSV 1241_ CSTAI 1246_ SGAIK 1251_ EHPFV 1256_ SSVDK 1261_ SSVLM 1266_ SVDSA 1271_ NTTIS 1276_ ACNIS 1281_ MLKTI 1286_ QGTDT 1291_ PCIAI 1296_ IPKCI 1301_ ESTPI 1306_ SATTE 1311_ GSSIS 1316_ SSMDD 1321_ KQLLI 1326_ SSSSA 1331_ SNLVS 1336_ TQYTS 1341_ VPTPS 1346_ IGNNL 1351_ PNLST 1356_ SSVLI 1361_ PPMGI 1366_ NNRFP 1371_ SEKIA 1376_ IPGSE 1381_ EQATV 1386_ SMGTT 1391_ VRAAL 1396_ SCSDS 1401_ VAVTD 1406_ SLVAH 1411_ PTVAM 1416_ FTGNM 1421_ LTINS 1426_ YDSPP 1431_ KLSAE 1436_ SLDKN 1441_ SGPRN 1446_ RADNS 1451_ GKPQQ 1456_ PPGGF 1461_ APAAI 1466_ NRSIP 1471_ CKVIV 1476_ DHSTT 1481_ LTSSL 1486_ SLTVS 1491_ VESSE 1496_ ASLDL 1501_ QGRPV 1506_ RTEAS 1511_ VQPVA 1516_ CPQVS 1521_ VISRP 1526_ EPVAN 1531_ EGIDH 1536_ SSTFI 1541_ AASAA 1546_ KQDSK 1551_ TLPAT 1556_ CTSLR 1561_ ELPLV 1566_ PDKLN 1571_ EPTAP 1576_ SHNFA 1581_ EQARG 1586_ PAPFK 1591_ SEADT 1596_ TCSNQ 1601_ YNPSN 1606_ RICWN 1611_ DDGMR 1616_ STGQP 1621_ LVTHS 1626_ GSSKQ 1631_ KEYLE 1636_ QSCPK 1641_ AIKTE 1646_ HANYL 1651_ NVSEL 1656_ HPRNL 1661_ VTNVA 1666_ LPVKS 1671_ ELHEA 1676_ DKGFR 1681_ MDTED 1686_ FPGPE 1691_ LPPPA 1696_ AEGAS 1701_ SVQQT 1706_ QNMKA 1711_ STSSP 1716_ MEEAI 1721_ SLATD 1726_ ALKRV 1731_ PGAGS 1736_ SGCRL 1741_ SSVEA 1746_ NNPLV 1751_ TQLLQ 1756_ GNLPL 1761_ EKVLP 1766_ QPRLG 1771_ AKLEI 1776_ NRLPL 1781_ PLQTT 1786_ SVGKT 1791_ APERN 1796_ VEIPP 1801_ SSPNP 1806_ DGKGY 1811_ LAGTL 1816_ APLQM 1821_ RKREN 1826_ HPKKR 1831_ VARTV 1836_ GEHTQ 1841_ VKCEP 1846_ GKLLV 1851_ EPDVK 1856_ GVPCV 1861_ ISSGI 1866_ SQLGH 1871_ SQPFK 1876_ QEWLN 1881_ KHSMQ 1886_ NRIVH 1891_ SPEVK 1896_ QQKRL 1901_ LPSCS 1906_ FQQNL 1911_ FHVDK 1916_ NGGFH 1921_ TDAGT 1926_ SHRQQ 1931_ FYQMP 1936_ VAARG 1941_ PIPTA 1946_ ALLQA 1951_ SSKTP 1956_ VGCNA 1961_ FAFNR 1966_ HLEQK 1971_ GLGEV 1976_ SLSSA 1981_ PHQLR 1986_ LANML 1991_ SPNMP 1996_ MKEGD 2001_ EVGGT 2006_ AHTMP 2011_ NKALV 2016_ HPPPP 2021_ PPPPP 2026_ PPPLA 2031_ LPPPP 2036_ PPPPP 2041_ LPPPL 2046_ PNAEV 2051_ PSDQK 2056_ QPPVT 2061_ METTK 2066_ RLSWP 2071_ QSTGI 2076_ CSNIK 2081_ SEPLS 2086_ FEEGL 2091_ SSSCE 2096_ LGMKQ 2101_ VSYDQ 2106_ NEMKE 2111_ QLKAF 2116_ ALKSA 2121_ DFSSY 2126_ LLSEP 2131_ QKPFT 2136_ QLAAQ 2141_ KMQVQ 2146_ QQQQL 2151_ CGNYP 2156_ TIHFG 2161_ STSFK 2166_ RAASA 2171_ IEKSI 2176_ GILGS 2181_ GSNPA 2186_ TGLSG 2191_ QNAQM 2196_ PVQNF 2201_ ADSSN 2206_ ADELE 2211_ LKCSC 2216_ RLKAM 2221_ IVCKG 2226_ CGAFC 2231_ HDDCI 2236_ GPSKL 2241_CVACL
1: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex and are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity)