Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1)
1_MDEGI 6_ PHLQE 11_ RQLLE 16_ HRDFI 21_ GLDYS 26_ SLYMC 31_ KPKRS 36_ MKRDD 41_ TKDTY 46_ KLPHR 51_ LIEKK 56_ RRDRI 61_ NECIA 66_ QLKDL 71_ LPEHL 76_ KLTTL 81_ GHLEK 86_ AVVLE 91_ LTLKH 96_ LKALT 101_ ALTEQ 106_ QHQKI 111_ IALQN 116_ GERSL 121_ KSPIQ 126_ SDLDA 131_ FHSGF 136_ QTCAK 141_ EVLQY 146_ LSRFE 151_ SWTPR 156_ EPRCV 161_ QLINH 166_ LHAVA 171_ TQFLP 176_ TPQLL 181_ TQQVP 186_ LSKGT 191_ GAPSA 196_ AGSAA 201_ APCLE 206_ RAGQK 211_ LEPLA 216_ YCVPV 221_ IQRTQ 226_ PSAEL 231_ AAEND 236_ TDTDS 241_ GYGGE 246_ AEARP 251_ DREKG 256_ KGAGA 261_ SRVTI 266_ KQEPP 271_ GEDSP 276_ APKRM 281_ KLDSR 286_ GGGSG 291_ GGPGG 296_ GAAAA 301_ AAALL 306_ GPDPA 311_ AAAAL 316_ LRPDA 321_ ALLSS 326_ LVAFG 331_ GGGGA 336_ PFPQP 341_ AAAAA 346_ PFCLP 351_ FCFLS 356_ PSAAA 361_ AYVQP 366_ FLDKS 371_ GLEKY 376_ LYPAA 381_ AAAPF 386_ PLLYP 391_ GIPAP 396_ AAAAA 401_ AAAAA 406_ AAAAA 411_ AFPCL 416_ SSVLS 421_ PPPEK 426_ AGAAA 431_ ATLLP 436_ HEVAP 441_ LGAPH 446_ PQHPH 451_ GRTHL 456_ PFAGP 461_ REPGN 466_ PESSA 471_ QEDPS 476_QPGKE
1: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity)