Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8)
1_MAPGR 6_ AVAGL 11_ LLLAA 16_ AGLGG 21_ VAEGP 26_ GLAFS 31_ EDVLS 36_ VFGAN 41_ LSLSA 46_ AQLQH 51_ LLEQM 56_ GAASR 61_ VGVPE 66_ PGQLH 71_ FNQCL 76_ TAEEI 81_ FSLHG 86_ FSNAT 91_ QITSS 96_ KFSVI 101_ CPAVL 106_ QQLNF 111_ HPCED 116_ RPKHK 121_ TRPSH 126_ SEVWG 131_ YGFLS 136_ VTIIN 141_ LASLL 146_ GLILT 151_ PLIKK 156_ SYFPK 161_ ILTFF 166_ VGLAI 171_ GTLFS 176_ NAIFQ 181_ LIPEA 186_ FGFDP 191_ KVDSY 196_ VEKAV 201_ AVFGG 206_ FYLLF 211_ FFERM 216_ LKMLL 221_ KTYGQ 226_ NGHTH 231_ FGNDN 236_ FGPQE 241_ KTHQP 246_ KALPA 251_ INGVT 256_ CYANP 261_ AVTEA 266_ NGHIH 271_ FDNVS 276_ VVSLQ 281_ DGKKE 286_ PSSCT 291_ CLKGP 296_ KLSEI 301_ GTIAW 306_ MITLC 311_ DALHN 316_ FIDGL 321_ AIGAS 326_ CTLSL 331_ LQGLS 336_ TSIAI 341_ LCEEF 346_ PHELG 351_ DFVIL 356_ LNAGM 361_ STRQA 366_ LLFNF 371_ LSACS 376_ CYVGL 381_ AFGIL 386_ VGNNF 391_ APNII 396_ FALAG 401_ GMFLY 406_ ISLAD 411_ MFPEM 416_ NDMLR 421_ EKVTG 426_ RKTDF 431_ TFFMI 436_ QNAGM 441_ LTGFT 446_ AILLI 451_TLYAG
1: Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:26637978, PubMed:29337306, PubMed:29453449). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:27166256, PubMed:31699897). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:27466201). May also transport iron and cobalt through membranes (PubMed:22898811). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290, PubMed:28056086). Protects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PubMed:26637978, PubMed:31699897). With manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PubMed:19401385)