STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2)
1_MSLLD 6_ CFCTS 11_ RTQVE 16_ SLRPE 21_ KQSET 26_ SIHQY 31_ LVDEP 36_ TLSWS 41_ RPSTR 46_ ASEVL 51_ CSTNV 56_ SHYEL 61_ QVEIG 66_ RGFDN 71_ LTSVH 76_ LARHT 81_ PTGTL 86_ VTIKI 91_ TNLEN 96_ CNEER 101_ LKALQ 106_ KAVIL 111_ SHFFR 116_ HPNIT 121_ TYWTV 126_ FTVGS 131_ WLWVI 136_ SPFMA 141_ YGSAS 146_ QLLRT 151_ YFPEG 156_ MSETL 161_ IRNIL 166_ FGAVR 171_ GLNYL 176_ HQNGC 181_ IHRSI 186_ KASHI 191_ LISGD 196_ GLVTL 201_ SGLSH 206_ LHSLV 211_ KHGQR 216_ HRAVY 221_ DFPQF 226_ STSVQ 231_ PWLSP 236_ ELLRQ 241_ DLHGY 246_ NVKSD 251_ IYSVG 256_ ITACE 261_ LASGQ 266_ VPFQD 271_ MHRTQ 276_ MLLQK 281_ LKGPP 286_ YSPLD 291_ ISIFP 296_ QSESR 301_ MKNSQ 306_ SGVDS 311_ GIGES 316_ VLVSS 321_ GTHTV 326_ NSDRL 331_ HTPSS 336_ KTFSP 341_ AFFSL 346_ VQLCL 351_ QQDPE 356_ KRPSA 361_ SSLLS 366_ HVFFK 371_ QMKEE 376_ SQDSI 381_ LSLLP 386_ PAYNK 391_ PSISL 396_ PPVLP 401_ WTEPE 406_ CDFPD 411_EKDSY
1: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity)