Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)
1_MDGED 6_ IPDFS 11_ SLKEE 16_ TAYWK 21_ ELSLK 26_ YKQSF 31_ QEARD 36_ ELVEF 41_ QEGSR 46_ ELEAE 51_ LEAQL 56_ VQAEQ 61_ RNRDL 66_ QADNQ 71_ RLKYE 76_ VEALK 81_ EKLEH 86_ QYAQS 91_ YKQVS 96_ VLEDD 101_ LSQTR 106_ AIKEQ 111_ LHKYV 116_ RELEQ 121_ ANDDL 126_ ERAKR 131_ ATIVS 136_ LEDFE 141_ QRLNQ 146_ AIERN 151_ AFLES 156_ ELDEK 161_ ESLLV 166_ SVQRL 171_ KDEAR 176_ DLRQE 181_ LAVRE 186_ RQQEV 191_ TRKSA 196_ PSSPT 201_ LDCEK 206_ MDSAV 211_ QASLS 216_ LPATP 221_ VGKGT 226_ ENTFP 231_ SPKAI 236_ PNGFG 241_ TSPLT 246_ PSARI 251_ SALNI 256_ VGDLL 261_ RKVGA 266_ LESKL 271_ AACRN 276_ FAKDQ 281_ ASRKS 286_ YISGN 291_ VNCGV 296_ LNGNG 301_ TKFSR 306_ SGHTS 311_ FFDKG 316_ AVNGF 321_ DPAPP 326_ PPGLG 331_ SSRPS 336_SAPGM
1: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709)