Probable G-protein coupled receptor 88 (Striatum-specific G-protein coupled receptor)
1_MTNSS 6_ STSTS 11_ STTGG 16_ SLLLL 21_ CEEEE 26_ SWAGR 31_ RIPVS 36_ LLYSG 41_ LAIGG 46_ TLANG 51_ MVIYL 56_ VSSFR 61_ KLQTT 66_ SNAFI 71_ VNGCA 76_ ADLSV 81_ CALWM 86_ PQEAV 91_ LGLLP 96_ TGSAE 101_ PPADW 106_ DGAGG 111_ SYRLL 116_ RGGLL 121_ GLGLT 126_ VSLLS 131_ HCLVA 136_ LNRYL 141_ LITRA 146_ PATYQ 151_ ALYQR 156_ RHTAG 161_ MLALS 166_ WALAL 171_ GLVLL 176_ LPPWA 181_ PRPGA 186_ APPRV 191_ HYPAL 196_ LAAAA 201_ LLAQT 206_ ALLLH 211_ CYLGI 216_ VRRVR 221_ VSVKR 226_ VSVLN 231_ FHLLH 236_ QLPGC 241_ AAAAA 246_ AFPGA 251_ QHAPG 256_ PGGAA 261_ HPAQA 266_ QPLPP 271_ ALHPR 276_ RAQRR 281_ LSGLS 286_ VLLLC 291_ CVFLL 296_ ATQPL 301_ VWVSL 306_ ASGFS 311_ LPVPW 316_ GVQAA 321_ SWLLC 326_ CALSA 331_ LNPLL 336_ YTWRN 341_ EEFRR 346_ SVRSV 351_ LPGVG 356_ DAAAA 361_ AVAAT 366_ AVPAV 371_ SQAQL 376_GTRAA
1: Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (PubMed:35501348). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (PubMed:23936473). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (PubMed:23936473)