Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)]
1_MHRLI 6_ FVYTL 11_ ICANF 16_ CSCRD 21_ TSATP 26_ QSASI 31_ KALRN 36_ ANLRR 41_ DESNH 46_ LTDLY 51_ RRDET 56_ IQVKG 61_ NGYVQ 66_ SPRFP 71_ NSYPR 76_ NLLLT 81_ WRLHS 86_ QENTR 91_ IQLVF 96_ DNQFG 101_ LEEAE 106_ NDICR 111_ YDFVE 116_ VEDIS 121_ ETSTI 126_ IRGRW 131_ CGHKE 136_ VPPRI 141_ KSRTN 146_ QIKIT 151_ FKSDD 156_ YFVAK 161_ PGFKI 166_ YYSLL 171_ EDFQP 176_ AAASE 181_ TNWES 186_ VTSSI 191_ SGVSY 196_ NSPSV 201_ TDPTL 206_ IADAL 211_ DKKIA 216_ EFDTV 221_ EDLLK 226_ YFNPE 231_ SWQED 236_ LENMY 241_ LDTPR 246_ YRGRS 251_ YHDRK 256_ SKVDL 261_ DRLND 266_ DAKRY 271_ SCTPR 276_ NYSVN 281_ IREEL 286_ KLANV 291_ VFFPR 296_ CLLVQ 301_ RCGGN 306_ CGCGT 311_ VNWRS 316_ CTCNS 321_ GKTVK 326_ KYHEV 331_ LQFEP 336_ GHIKR 341_ RGRAK 346_ TMALV 351_ DIQLD 356_ HHERC 361_DCICS
1: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity)