COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG)
1_MSAVG 6_ AATPY 11_ LHHPG 16_ DSHSG 21_ RVSFL 26_ GAQLP 31_ PEVAA 36_ MARLL 41_ GDLDR 46_ STFRK 51_ LLKFV 56_ VSSLQ 61_ GEDCR 66_ EAVQR 71_ LGVSA 76_ NLPEE 81_ QLGAL 86_ LAGMH 91_ TLLQQ 96_ ALRLP 101_ PTSLK 106_ PDTFR 111_ DQLQE 116_ LCIPQ 121_ DLVGD 126_ LASVV 131_ FGSQR 136_ PLLDS 141_ VAQQQ 146_ GAWLP 151_ HVADF 156_ RWRVD 161_ VAIST 166_ SALAR 171_ SLQPS 176_ VLMQL 181_ KLSDG 186_ SAYRF 191_ EVPTA 196_ KFQEL 201_ RYSVA 206_ LVLKE 211_ MADLE 216_KRCER
1: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation (By similarity). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (By similarity). Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966)