Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6)
1_MAAGK 6_ SGGSA 11_ GEITF 16_ LEALA 21_ RSESK 26_ RDGGF 31_ KNNWS 36_ FDHEE 41_ ESEGD 46_ TDKDG 51_ TNLLS 56_ VDEDE 61_ DSETS 66_ KGKKL 71_ NRRSE 76_ IVANS 81_ SGEFI 86_ LKTYV 91_ RRNKS 96_ ESFKT 101_ LKGNP 106_ IGLNM 111_ LSNNK 116_ KLSEN 121_ TQNTS 126_ LCSGT 131_ VVHGR 136_ RFHHA 141_ HAQIP 146_ VVKTA 151_ AQSSL 156_ DRKER 161_ KEYPP 166_ HVQKV 171_ EINPV 176_ RLSRL 181_ QGVER 186_ IMKKT 191_ EESES 196_ QVEPE 201_ IKRKV 206_ QQKRH 211_ CSTYQ 216_ PTPPL 221_ SPASK 226_ KCLTH 231_ LEDLQ 236_ RNCRQ 241_ AITLN 246_ ESTGP 251_ LLRTS 256_ IHQNS 261_ GGQKS 266_ QNTGL 271_ TTKKF 276_ YGNNV 281_ EKVPI 286_ DIIVN 291_ CDDSK 296_ HTYLQ 301_ TNGKV 306_ ILPGA 311_ KIPKI 316_ TNLKE 321_ RKTSL 326_ SDLND 331_ PIILS 336_ SDDDD 341_ DNDRT 346_ NRRES 351_ ISPQP 356_ ADSAC 361_ SSPAP 366_ STGKV 371_ EAALN 376_ ENTCR 381_ AEREL 386_ RSIPE 391_ DSELN 396_ TVTLP 401_ RKARM 406_ KDQFG 411_ NSIIN 416_ TPLKR 421_ RKVFS 426_ QEPPD 431_ ALALS 436_ CQSSF 441_ DSVIL 446_ NCRSI 451_ RVGTL 456_ FRLLI 461_ EPVIF 466_ CLDFI 471_ KIQLD 476_ EPDHD 481_ PVEII 486_ LNTSD 491_ LTKCE 496_ WCNVR 501_ KLPVV 506_ FLQAI 511_ PAVYQ 516_ KLSIQ 521_ LQMNK 526_ EDKVW 531_ NDCKG 536_ VNKLT 541_ NLEEQ 546_ YIILI 551_ FQNGL 556_ DPPAN 561_ MVFES 566_ IINEI 571_ GIKNN 576_ ISNFF 581_ AKIPF 586_ EEANG 591_ RLVAC 596_ TRTYE 601_ ESIKG 606_ SCGQK 611_ ENKIK 616_ TVSFE 621_ SKIQL 626_ RSKQE 631_ FQFFD 636_ EEEET 641_ GENHT 646_ IFIGP 651_ VEKLI 656_ VYPPP 661_ PAKGG 666_ ISVTN 671_ EDLHC 676_ LNEGE 681_ FLNDV 686_ IIDFY 691_ LKYLV 696_ LEKLK 701_ KEDAD 706_ RIHIF 711_ SSFFY 716_ KRLNQ 721_ RERRN 726_ HETTN 731_ LSIQQ 736_ KRHGR 741_ VKTWT 746_ RHVDI 751_ FEKDF 756_ IFVPL 761_ NEAAH 766_ WFLAV 771_ VCFPG 776_ LEKPK 781_ YEPNP 786_ HYHEN 791_ AVIQK 796_ CSTVE 801_ DSCIS 806_ SSASE 811_ MESCS 816_ QNSSA 821_ KPVIK 826_ KMLNK 831_ KHCIA 836_ VIDSN 841_ PGQEE 846_ SDPRY 851_ KRNIC 856_ SVKYS 861_ VKKIN 866_ HTASE 871_ NEEFN 876_ KGEST 881_ SQKVA 886_ DRTKS 891_ ENGLQ 896_ NESLS 901_ STHHT 906_ DGLSK 911_ IRLNY 916_ SDESP 921_ EAGKM 926_ LEDEL 931_ VDFSE 936_ DQDNQ 941_ DDSSD 946_ DGFLA 951_ DDNCS 956_ SEIGQ 961_ WHLKP 966_ TICKQ 971_ PCILL 976_ MDSLR 981_ GPSRS 986_ NVVKI 991_ LREYL 996_ EVEWE 1001_ VKKGS 1006_ KRSFS 1011_ KDVMK 1016_ GSNPK 1021_ VPQQN 1026_ NFSDC 1031_ GVYVL 1036_ QYVES 1041_ FFENP 1046_ ILSFE 1051_ LPMNL 1056_ ANWFP 1061_ PPRMR 1066_ TKREE 1071_ IRNII 1076_ LKLQE 1081_ DQSKE 1086_ KRKHK 1091_ DTYST 1096_ EAPLG 1101_ EGTEQ 1106_YVNSI
1: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination