Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4)
1_MGLLD 6_ SEPGS 11_ VLNVV 16_ STALN 21_ DTVEF 26_ YRWTW 31_ SIADK 36_ RVENW 41_ PLMQS 46_ PWPTL 51_ SISTL 56_ YLLFV 61_ WLGPK 66_ WMKDR 71_ EPFQM 76_ RLVLI 81_ IYNFG 86_ MVLLN 91_ LFIFR 96_ ELFMG 101_ SYNAG 106_ YSYIC 111_ QSVDY 116_ SNNVH 121_ EVRIA 126_ AALWW 131_ YFVSK 136_ GVEYL 141_ DTVFF 146_ ILRKK 151_ NNQVS 156_ FLHVY 161_ HHCTM 166_ FTLWW 171_ IGIKW 176_ VAGGQ 181_ AFFGA 186_ QLNSF 191_ IHVIM 196_ YSYYG 201_ LTAFG 206_ PWIQK 211_ YLWWK 216_ RYLTM 221_ LQLIQ 226_ FHVTI 231_ GHTAL 236_ SLYTD 241_ CPFPK 246_ WMHWA 251_ LIAYA 256_ ISFIF 261_ LFLNF 266_ YIRTY 271_ KEPKK 276_ PKAGK 281_ TAMNG 286_ ISANG 291_ VSKSE 296_ KQLMI 301_ ENGKK 306_QKNGK
1: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development