ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)
1_MKLKD 6_ TKSRP 11_ KQSSC 16_ GKFQT 21_ KGIKV 26_ VGKWK 31_ EVKID 36_ PNMFA 41_ DGQMD 46_ DLVCF 51_ EELTD 56_ YQLVS 61_ PAKNP 66_ SSLFS 71_ KEAPK 76_ RKAQA 81_ VSEEE 86_ EEEEG 91_ KSSSP 96_ KKKIK 101_ LKKSK 106_ NVATE 111_ GTSTQ 116_ KEFEV 121_ KDPEL 126_ EAQGD 131_ DMVCD 136_ DPEAG 141_ EMTSE 146_ NLVQT 151_ APKKK 156_ KNKGK 161_ KGLEP 166_ SQSTA 171_ AKVPK 176_ KAKTW 181_ IPEVH 186_ DQKAD 191_ VSAWK 196_ DLFVP 201_ RPVLR 206_ ALSFL 211_ GFSAP 216_ TPIQA 221_ LTLAP 226_ AIRDK 231_ LDILG 236_ AAETG 241_ SGKTL 246_ AFAIP 251_ MIHAV 256_ LQWQK 261_ RNAAP 266_ PPSNT 271_ EAPPG 276_ ETRTE 281_ AGAET 286_ RSPGK 291_ AEAES 296_ DALPD 301_ DTVIE 306_ SEALP 311_ SDIAA 316_ EARAK 321_ TGGTV 326_ SDQAL 331_ LFGDD 336_ DAGEG 341_ PSSLI 346_ REKPV 351_ PKQNE 356_ NEEEN 361_ LDKEQ 366_ TGNLK 371_ QELDD 376_ KSATC 381_ KAYPK 386_ RPLLG 391_ LVLTP 396_ TRELA 401_ VQVKQ 406_ HIDAV 411_ ARFTG 416_ IKTAI 421_ LVGGM 426_ STQKQ 431_ QRMLN 436_ RRPEI 441_ VVATP 446_ GRLWE 451_ LIKEK 456_ HYHLR 461_ NLRQL 466_ RCLVV 471_ DEADR 476_ MVEKG 481_ HFAEL 486_ SQLLE 491_ MLNDS 496_ QYNPK 501_ RQTLV 506_ FSATL 511_ TLVHQ 516_ APARI 521_ LHKKH 526_ TKKMD 531_ KTAKL 536_ DLLMQ 541_ KIGMR 546_ GKPKV 551_ IDLTR 556_ NEATV 561_ ETLTE 566_ TKIHC 571_ ETDEK 576_ DFYLY 581_ YFLMQ 586_ YPGRS 591_ LVFAN 596_ SISCI 601_ KRLSG 606_ LLKVL 611_ DIMPL 616_ TLHAC 621_ MHQKQ 626_ RLRNL 631_ EQFAR 636_ LEDCV 641_ LLATD 646_ VAARG 651_ LDIPK 656_ VQHVI 661_ HYQVP 666_ RTSEI 671_ YVHRS 676_ GRTAR 681_ ATNEG 686_ LSLML 691_ IGPED 696_ VINFK 701_ KIYKT 706_ LKKDE 711_ DIPLF 716_ PVQTK 721_ YMDVV 726_ KERIR 731_ LARQI 736_ EKSEY 741_ RNFQA 746_ CLHNS 751_ WIEQA 756_ AAALE 761_ IELEE 766_ DMYKG 771_ GKADQ 776_ QEERR 781_ RQKQM 786_ KVLKK 791_ ELRHL 796_ LSQPL 801_ FTESQ 806_ KTKYP 811_ TQSGK 816_ PPLLV 821_ SAPSK 826_ SESAL 831_ SCLSK 836_ QKKKK 841_ TKKPK 846_ EPQPE 851_QPQPS
1: ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:24980433). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation (PubMed:25867071). Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity)
2: (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270)