Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 3) (NLI-IF) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1)
1_MDSSA 6_ VITQI 11_ SKEEA 16_ RGPLR 21_ GKGDQ 26_ KSAAS 31_ QKPRS 36_ RGILH 41_ SLFCC 46_ VCRDD 51_ GEALP 56_ AHSGA 61_ PLLVE 66_ ENGAI 71_ PKQTP 76_ VQYLL 81_ PEAKA 86_ QDSDK 91_ ICVVI 96_ DLDET 101_ LVHSS 106_ FKPVN 111_ NADFI 116_ IPVEI 121_ DGVVH 126_ QVYVL 131_ KRPHV 136_ DEFLQ 141_ RMGEL 146_ FECVL 151_ FTASL 156_ AKYAD 161_ PVADL 166_ LDKWG 171_ AFRAR 176_ LFRES 181_ CVFHR 186_ GNYVK 191_ DLSRL 196_ GRDLR 201_ RVLIL 206_ DNSPA 211_ SYVFH 216_ PDNAV 221_ PVASW 226_ FDNMS 231_ DTELH 236_ DLLPF 241_ FEQLS 246_ RVDDV 251_ YSVLR 256_QPRPG
1: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells