PSME3-interacting protein (NEFA-interacting nuclear protein NIP30) (PA28G-interacting protein)
1_MDGGD 6_ DGNLI 11_ IKKRF 16_ VSEAE 21_ LDERR 26_ KRRQE 31_ EWEKV 36_ RKPED 41_ PEECP 46_ EEVYD 51_ PRSLY 56_ ERLQE 61_ QKDRK 66_ QQEYE 71_ EQFKF 76_ KNMVR 81_ GLDED 86_ ETNFL 91_ DEVSR 96_ QQELI 101_ EKQRR 106_ EEELK 111_ ELKEY 116_ RNNLK 121_ KVGIS 126_ QENKK 131_ EVEKK 136_ LTVKP 141_ IETKN 146_ KFSQA 151_ KLLAG 156_ AVKHK 161_ SSESG 166_ NSVKR 171_ LKPDP 176_ EPDDK 181_ NQEPS 186_ SCKSL 191_ GNTSL 196_ SGPSI 201_ HCPSA 206_ AVCIG 211_ ILPGL 216_ GAYSG 221_ SSDSE 226_ SSSDS 231_ EGTIN 236_ ATGKI 241_ VSSIF 246_RTNTF
1: Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus