High affinity choline transporter 1 (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7)
1_MAFHV 6_ EGLIA 11_ IIVFY 16_ LLILL 21_ VGIWA 26_ AWRTK 31_ NSGSA 36_ EERSE 41_ AIIVG 46_ GRDIG 51_ LLVGG 56_ FTMTA 61_ TWVGG 66_ GYING 71_ TAEAV 76_ YVPGY 81_ GLAWA 86_ QAPIG 91_ YSLSL 96_ ILGGL 101_ FFAKP 106_ MRSKG 111_ YVTML 116_ DPFQQ 121_ IYGKR 126_ MGGLL 131_ FIPAL 136_ MGEMF 141_ WAAAI 146_ FSALG 151_ ATISV 156_ IIDVD 161_ MHISV 166_ IISAL 171_ IATLY 176_ TLVGG 181_ LYSVA 186_ YTDVV 191_ QLFCI 196_ FVGLW 201_ ISVPF 206_ ALSHP 211_ AVADI 216_ GFTAV 221_ HAKYQ 226_ KPWLG 231_ TVDSS 236_ EVYSW 241_ LDSFL 246_ LLMLG 251_ GIPWQ 256_ AYFQR 261_ VLSSS 266_ SATYA 271_ QVLSF 276_ LAAFG 281_ CLVMA 286_ IPAIL 291_ IGAIG 296_ ASTDW 301_ NQTAY 306_ GLPDP 311_ KTTEE 316_ ADMIL 321_ PIVLQ 326_ YLCPV 331_ YISFF 336_ GLGAV 341_ SAAVM 346_ SSADS 351_ SILSA 356_ SSMFA 361_ RNIYQ 366_ LSFRQ 371_ NASDK 376_ EIVWV 381_ MRITV 386_ FVFGA 391_ SATAM 396_ ALLTK 401_ TVYGL 406_ WYLSS 411_ DLVYI 416_ VIFPQ 421_ LLCVL 426_ FVKGT 431_ NTYGA 436_ VAGYV 441_ SGLFL 446_ RITGG 451_ EPYLY 456_ LQPLI 461_ FYPGY 466_ YPDDN 471_ GIYNQ 476_ KFPFK 481_ TLAMV 486_ TSFLT 491_ NICIS 496_ YLAKY 501_ LFESG 506_ TLPPK 511_ LDVFD 516_ AVVAR 521_ HSEEN 526_ MDKTI 531_ LVKNE 536_ NIKLD 541_ ELALV 546_ KPRQS 551_ MTLSS 556_ TFTNK 561_ EAFLD 566_ VDSSP 571_EGSGT
1: High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:11027560, PubMed:11068039, PubMed:12237312, PubMed:12969261, PubMed:17005849, PubMed:23132865, PubMed:23141292, PubMed:27569547). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (PubMed:17005849). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (PubMed:11068039, PubMed:12237312, PubMed:17005849). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (PubMed:27569547). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (PubMed:11027560). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (PubMed:12969261, PubMed:15953352)