Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2)
1_MADEI 6_ DFTTG 11_ DAGAS 16_ STYPM 21_ QCSAL 26_ RKNGF 31_ VVLKG 36_ RPCKI 41_ VEMST 46_ SKTGK 51_ HGHAK 56_ VHLVG 61_ IDIFT 66_ GKKYE 71_ DICPS 76_ THNMD 81_ VPNIK 86_ RNDYQ 91_ LICIQ 96_ DGYLS 101_ LLTET 106_ GEVRE 111_ DLKLP 116_ EGELG 121_ KEIEG 126_ KYNAG 131_ EDVQV 136_ SVMCA 141_ MSEEY 146_AVAIK
1: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity)