WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
1_MNPAS 6_ APPPL 11_ PPPGQ 16_ QVIHV 21_ TQDLD 26_ TDLEA 31_ LFNSV 36_ MNPKP 41_ SSWRK 46_ KILPE 51_ SFFKE 56_ PDSGS 61_ HSRQS 66_ STDSS 71_ GGHPG 76_ PRLAG 81_ GAQHV 86_ RSHSS 91_ PASLQ 96_ LGTGA 101_ GAAGS 106_ PAQQH 111_ AHLRQ 116_ QSYDV 121_ TDELP 126_ LPPGW 131_ EMTFT 136_ ATGQR 141_ YFLNH 146_ IEKIT 151_ TWQDP 156_ RKAMN 161_ QPLNH 166_ MNLHP 171_ AVSST 176_ PVPQR 181_ SMAVS 186_ QPNLV 191_ MNHQH 196_ QQQMA 201_ PSTLS 206_ QQNHP 211_ TQNPP 216_ AGLMS 221_ MPNAL 226_ TTQQQ 231_ QQQKL 236_ RLQRI 241_ QMERE 246_ RIRMR 251_ QEELM 256_ RQEAA 261_ LCRQL 266_ PMEAE 271_ TLAPV 276_ QAAVN 281_ PPTMT 286_ PDMRS 291_ ITNNS 296_ SDPFL 301_ NGGPY 306_ HSREQ 311_ STDSG 316_ LGLGC 321_ YSVPT 326_ TPEDF 331_ LSNVD 336_ EMDTG 341_ ENAGQ 346_ TPMNI 351_ NPQQT 356_ RFPDF 361_ LDCLP 366_ GTNVD 371_ LGTLE 376_ SEDLI 381_ PLFND 386_ VESAL 391_NKSEP
1: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018)