PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14)
1_MALPR 6_ PSEAV 11_ PQDKV 16_ CYPPE 21_ SSPQN 26_ LAAYY 31_ TPFPS 36_ YGHYR 41_ NSLAT 46_ VEEDF 51_ QPFRQ 56_ LEAAA 61_ SAAPA 66_ MPPFP 71_ FRMAP 76_ PLLSP 81_ GLGLQ 86_ REPLY 91_ DLPWY 96_ SKLPP 101_ WYPIP 106_ HVPRE 111_ VPPFL 116_ SSSHE 121_ YAGAS 126_ SEDLG 131_ HQIIG 136_ GDNES 141_ GPCCG 146_ PDTLI 151_ PPPPA 156_ DASLL 161_ PEGLR 166_ TSQLL 171_ PCSPS 176_ KQSED 181_ GPKPS 186_ NQEGK 191_ SPARF 196_ QFTEE 201_ DLHFV 206_ LYGVT 211_ PSLEH 216_ PASLH 221_ HAISG 226_ LLVPP 231_ DSSGS 236_ DSLPQ 241_ TLDKD 246_ SLQLP 251_ EGLCL 256_ MQTVF 261_ GEVPH 266_ FGVFC 271_ SSFIA 276_ KGVRF 281_ GPFQG 286_ KVVNA 291_ SEVKT 296_ YGDNS 301_ VMWEI 306_ FEDGH 311_ LSHFI 316_ DGKGG 321_ TGNWM 326_ SYVNC 331_ ARFPK 336_ EQNLV 341_ AVQCQ 346_ GHIFY 351_ ESCKE 356_ IHQNQ 361_ ELLVW 366_ YGDCY 371_ EKFLD 376_ IPVSL 381_ QVTEP 386_ GKQPS 391_ GPSEE 396_ SAEGY 401_ RCERC 406_ GKVFT 411_ YKYYR 416_ DKHLK 421_ YTPCV 426_ DKGDR 431_ KFPCS 436_ LCKRS 441_ FEKRD 446_ RLRIH 451_ ILHVH 456_ EKHRP 461_ HKCST 466_ CGKCF 471_ SQSSS 476_ LNKHM 481_ RVHSG 486_ DRPYQ 491_ CVYCT 496_ KRFTA 501_ SSILR 506_ THIRQ 511_ HSGEK 516_ PFKCK 521_ YCGKS 526_ FASHA 531_ AHDSH 536_ VRRSH 541_ KEDDG 546_ CSCSI 551_ CGKIF 556_ SDQET 561_ FYSHM 566_KFHED
1: Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'