Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide]
1_MLGAR 6_ LRLWV 11_ CALCS 16_ VCSMS 21_ VLRAY 26_ PNASP 31_ LLGSS 36_ WGGLI 41_ HLYTA 46_ TARNS 51_ YHLQI 56_ HKNGH 61_ VDGAP 66_ HQTIY 71_ SALMI 76_ RSEDA 81_ GFVVI 86_ TGVMS 91_ RRYLC 96_ MDFRG 101_ NIFGS 106_ HYFDP 111_ ENCRF 116_ QHQTL 121_ ENGYD 126_ VYHSP 131_ QYHFL 136_ VSLGR 141_ AKRAF 146_ LPGMN 151_ PPPYS 156_ QFLSR 161_ RNEIP 166_ LIHFN 171_ TPIPR 176_ RHTRS 181_ AEDDS 186_ ERDPL 191_ NVLKP 196_ RARMT 201_ PAPAS 206_ CSQEL 211_ PSAED 216_ NSPMA 221_ SDPLG 226_ VVRGG 231_ RVNTH 236_ AGGTG 241_ PEGCR 246_PFAKF
1: Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132)