Carbohydrate sulfotransferase 6 (Corneal N-acetylglucosamine-6-O-sulfotransferase) (C-GlcNAc6ST) (hCGn6ST) (EC 2.8.2.21) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta) (GST4-beta) (N-acetylglucosamine 6-O-sulfotransferase 5) (GlcNAc6ST-5) (Gn6st-5)
1_MWLPR 6_ VSSTA 11_ VTALL 16_ LAQTF 21_ LLLFL 26_ VSRPG 31_ PSSPA 36_ GGEAR 41_ VHVLV 46_ LSSWR 51_ SGSSF 56_ VGQLF 61_ NQHPD 66_ VFYLM 71_ EPAWH 76_ VWTTL 81_ SQGSA 86_ ATLHM 91_ AVRDL 96_ VRSVF 101_ LCDMD 106_ VFDAY 111_ LPWRR 116_ NLSDL 121_ FQWAV 126_ SRALC 131_ SPPAC 136_ SAFPR 141_ GAISS 146_ EAVCK 151_ PLCAR 156_ QSFTL 161_ AREAC 166_ RSYSH 171_ VVLKE 176_ VRFFN 181_ LQVLY 186_ PLLSD 191_ PALNL 196_ RIVHL 201_ VRDPR 206_ AVLRS 211_ REQTA 216_ KALAR 221_ DNGIV 226_ LGTNG 231_ TWVEA 236_ DPGLR 241_ VVREV 246_ CRSHV 251_ RIAEA 256_ ATLKP 261_ PPFLR 266_ GRYRL 271_ VRFED 276_ LAREP 281_ LAEIR 286_ ALYAF 291_ TGLSL 296_ TPQLE 301_ AWIHN 306_ ITHGS 311_ GPGAR 316_ REAFK 321_ TSSRN 326_ ALNVS 331_ QAWRH 336_ ALPFA 341_ KIRRV 346_ QELCA 351_ GALQL 356_ LGYRP 361_ VYSED 366_ EQRNL 371_ ALDLV 376_ LPRGL 381_ NGFTW 386_ASSTA
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan (PubMed:11278593, PubMed:11352640, PubMed:12218059, PubMed:17690104). Cooperates with B4GALT4 galactosyltransferase and B3GNT7 N-acetylglucosaminyltransferase to construct and elongate the sulfated disaccharide unit [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Involved in biosynthesis of keratan sulfate in cornea, with an impact on proteoglycan fibril organization and corneal transparency (PubMed:11278593, PubMed:12218059, PubMed:17690104). Involved in sulfation of endothelial mucins such as GLYCAM1 (PubMed:11352640)