Single-stranded DNA cytosine deaminase (EC 3.5.4.38) (Activation-induced cytidine deaminase) (AID) (Cytidine aminohydrolase)
1_MDSLL 6_ MNRRK 11_ FLYQF 16_ KNVRW 21_ AKGRR 26_ ETYLC 31_ YVVKR 36_ RDSAT 41_ SFSLD 46_ FGYLR 51_ NKNGC 56_ HVELL 61_ FLRYI 66_ SDWDL 71_ DPGRC 76_ YRVTW 81_ FTSWS 86_ PCYDC 91_ ARHVA 96_ DFLRG 101_ NPNLS 106_ LRIFT 111_ ARLYF 116_ CEDRK 121_ AEPEG 126_ LRRLH 131_ RAGVQ 136_ IAIMT 141_ FKDYF 146_ YCWNT 151_ FVENH 156_ ERTFK 161_ AWEGL 166_ HENSV 171_ RLSRQ 176_ LRRIL 181_ LPLYE 186_ VDDLR 191_DAFRT
1: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894)